With the continuous development and maturity of the chemical industry, our company has become more and more experienced in the long road of focusing on pharmaceutical raw materials, not only in the control of product quality, but also in the supervision of employees before and after sales, and the introduction of product equipment. The strict requirements of upgrading and upgrading have made our company go further and further, the span of customer areas is getting wider and wider, and the business scope is also expanding year by year, including the development and research of cosmetic raw materials. In addition, our company currently has new tasks in progress in terms of pharmaceutical raw materials. We are now building a production area of more than 7,000 square meters to specialize in the production of resveratrol, striving to become the main producer of resveratrol. supplier.
So what exactly is resveratrol? Let me give you a brief introduction.
Resveratrol (3-4'-5-trihydroxystilbene) is a non-flavonoid polyphenol compound whose chemical name is 3,4',5-trihydroxy-1,2-diphenylethylene (3,4 ',5-Stilbenetriol), the molecular formula is C14H12O3, and the molecular weight is 228.25. The appearance of pure resveratrol is white to light yellow powder, odorless, difficult to dissolve in water, easily soluble in organic solvents such as ether, chloroform, methanol, ethanol, acetone, ethyl acetate, etc., with a melting point of 253~255°C. Sublimation temperature is 261℃. It can appear red with alkaline solutions such as ammonia water, and can react with ferric chloride-potassium ferricyanide to develop color. This property can be used to identify resveratrol.
Natural resveratrol has two structures, cis and trans. It mainly exists in trans conformation in nature. The two structures can be combined with glucose respectively to form cis and trans resveratrol glycosides. The cis- and trans-resveratrol glycosides can release resveratrol under the action of glycosidases in the intestine. Under UV light irradiation, trans-resveratrol can be converted into the cis-isomer.
Resveratrol produces fluorescence under 366nm ultraviolet light. Jeandet et al. determined the UV spectral characteristics of resveratrol and its infrared absorption peaks at 2800~3500cm (OH bond) and 965cm (trans form of double bond). Experiments have shown that trans-resveratrol is stable even if it is left for several months, except in high pH buffers, as long as it is completely isolated from light.
Resveratrol has relatively low bioavailability in the body, with studies showing that the bioavailability of resveratrol metabolites in the small intestine and liver is approximately 1%. Resveratrol is rapidly metabolized in animals and reaches its peak value in plasma within 5 minutes. Metabolism studies in animals have found that resveratrol is mainly metabolized in mammals such as rats, pigs, dogs, etc. in the form of resveratrol sulfate esterification and glucuronidation products. Studies have confirmed that resveratrol is distributed in bound forms into different tissues of mammals, and resveratrol is more absorbed and distributed in organs with rich blood perfusion, such as liver, kidneys, heart and brain. Through research on the metabolism of resveratrol in the human body, it was found that the concentration of resveratrol in the plasma of normal humans showed a "double peak phenomenon" after oral administration, but there was no such phenomenon after iv administration (intravenous injection); the concentration of resveratrol in the plasma after oral administration The main products of alcohol metabolism are glucuronidation and sulfate esterification. After patients with colorectal cancer take resveratrol orally, the left colon absorbs less than the right side, and six metabolites, resveratrol-3-O-glucuronide and resveratrol-4′-O-glucuronide, are obtained. Resveratrol sulfate and glucuronide compounds such as glucuronide, resveratrol-3-O-sulfate, and resveratrol-4′-O-sulfate.
