Hot selling CAS 16941-32-5 Glucagon with high purity high quality good price hot sale stock door to door delivery and high customer satisfaction

The main function of glucagon is to promote glycogen decomposition and produce glucose to raise blood sugar; Secondly, the level of cyclic adenosine monophosphate (cAMP) can be increased by adenylate cyclase, thus activating protein kinase, activating lipase in adipose tissue and promoting lipolysis. Activate myocardial adenylate cyclase system, promote the activity of myocardial phosphorylase, increase the accumulation of calcium in myocardium, thereby enhancing myocardial contractility, increasing cardiac output and raising blood pressure; It can also promote the secretion of islet Chemicalbook, somatostatin, thyroxine and calcitonin; Promote the release of catecholamine from sympathetic nerve and chromaffin cells. Glucagon, insulin and somatostatin regulate each other to keep blood sugar in the normal range. The secretion of glucagon is inversely proportional to the blood glucose concentration, and at the same time, the secretion of glucagon is also affected by amino acids, plasma free fatty acid content, α -adrenergic receptor stimulator (norepinephrine), auxin release inhibitory hormone and so on.

Glucagon is a single-chain polypeptide hormone synthesized and secreted by islet α2 cells. It is a physiological antagonist of insulin. The effect on metabolism is similar to that of adrenaline, and it has the following functions: 1. The function of raising blood sugar: it can activate the phosphorylase in the liver, promote the decomposition of liver glycogen and the heterogenesis of glycogen, and raise blood sugar. 2. Positive inotropic effect: it can increase intracellular cAMP content, enhance myocardial contractility, increase cardiac output and stroke work. Its positive inotropic effect can still be exerted after sufficient cardiac glycoside is applied, and it is not blocked by propranolol. Although it can increase heart rate and hypertension, it will not cause arrhythmia. The mechanism is as follows: ① Activation of adenylate cyclase makes adenosine triphosphate change into cyclic adenosine monophosphate, which enhances the myocardial contractility of Chemicalbook; ② Promote the decomposition of liver glycogen and raise the blood sugar level; ③ Promote insulin release, improve the utilization of glucose by myocardium, and promote anaerobic glycolysis of myocardium, thus improving energy metabolism of myocardium. Combined with digitalis cardiac glycosides, it can increase the curative effect. 3. Effect on kidney: dilate renal blood vessels, improve renal blood flow and promote the excretion of sodium, potassium and calcium. 4. Effect on digestive system: It can cause smooth muscle relaxation of stomach and duodenum, small intestine and colon, inhibit peristalsis of stomach, small intestine and colon, and increase secretion of bile and intestinal fluid. 5. Effect on the secretory system: Excite adrenal medulla and promote the release of catecholamines. It can also promote the secretion of insulin, thyroid hormone, calcitonin and growth hormone.