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Dihexa CAS 1401708-83-5 China factory direct sales Safety shipping excellent Quality high costomers satisfaction Fast Delivery compectitive price High Purity

Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. 

 

 

 

    Product Description

    Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.

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    Product Application

    N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent.
    Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease.

    product specification

    Common Name Dihexa
    CAS Number 1401708-83-5
          Density  
    1.1±0.1 g/cm3
    Boiling Point  
    866.2±65.0 °C at 760 mmHg
    Molecular Formula
    C27H44N4O5
    Molecular Weight 504.662
        LogP  
    2.78
    EINECS
    227-005-2
    Vapour Pressure  
    0.0±0.3 mmHg at 25°C
    Index of Refraction 
    1.529

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