Ukuthengiswa okuqondile kwasefekthri I-Pregabalin CAS 148553-50-8 enekhwalithi engcono kakhulu nenani eliphansi kakhulu esitokweni esiphephile futhi esisheshayo sokulethwa kwemithi okumaphakathi

I-Pregabalin umuthi owela ngaphansi kwesigaba sezidakamizwa ezilwa nokuquleka. I-Pregabalin iphuma ku-gamma-aminobutyric acid (GABA), i-neurotransmitter ohlelweni lwezinzwa olumaphakathi. Ngokwesakhiwo, ihlobene ne-GABA ye-neurotransmitter evimbelayo, kodwa indlela yayo yokusebenza ihlukile. Ngokuya ngezakhiwo ezibonakalayo, i-pregabalin iqinile elicwebezelayo elimhlophe. Izici zayo zokuncibilika zihlanganisa ukungancibiliki emanzini kanye nokuncibilika ngokukhululekile kuzincibilikisi zemvelo ezishisayo. I-Pregabalin itholakala ngamafomu omthamo womlomo, njengamaphilisi noma amaphilisi, ukuze isetshenziswe njengomuthi.

I-Pregabalin ivame ukusetshenziselwa ukwelapha izimo ezihlukahlukene zezokwelapha, kuhlanganise nobuhlungu be-neuropathic, i-fibromyalgia, nezinhlobo ezithile zokuquleka. Isebenzisa imiphumela yayo yokwelapha ngokubophezela ku-alpha-2-delta subunit yeziteshi ze-calcium ezine-voltage-gated ohlelweni lwezinzwa olumaphakathi. Lokhu kubophezela kushintsha ukungena kwe-calcium ion, kunciphisa ukukhululwa kwama-neurotransmitters, futhi ngaleyo ndlela kunciphise ukujabula kwamangqamuzana ezinzwa.