Ngokuthuthuka okuqhubekayo kanye nokuvuthwa kwemboni yamakhemikhali, inkampani yethu isibe nolwazi olunzulu emgwaqeni omude wokugxila ezintweni ezingavuthiwe zemithi, hhayi kuphela ekulawuleni izinga lomkhiqizo, kodwa nasekugadweni kwabasebenzi ngaphambi nangemva kokuthengisa. , kanye nokwethulwa kwempahla yomkhiqizo. Izidingo eziqinile zokuthuthukisa nokuthuthukisa zenze inkampani yethu yaqhubekela phambili, isikhathi sezindawo zamakhasimende siya ngokuya siba banzi, futhi nobubanzi bebhizinisi buyakhula unyaka nonyaka, okuhlanganisa ukuthuthukiswa nokucwaninga kwezinto zokusetshenziswa zezimonyo. Ngaphezu kwalokho, inkampani yethu njengamanje inemisebenzi emisha eqhubekayo mayelana nezinto zokusetshenziswa kwemithi. Manje sakha indawo yokukhiqiza engaphezu kuka-7,000 square metres ukuze sigxile ekukhiqizeni i-resveratrol, silwela ukuba ngumkhiqizi oyinhloko we-resveratrol. umphakeli.
Ngakho-ke iyini ngempela i-resveratrol? Ake ngikunike isingeniso esifushane.
I-Resveratrol (3-4'-5-trihydroxystilbene) iyinhlanganisela engeyona i-flavonoid polyphenol igama layo lekhemikhali lingu-3,4',5-trihydroxy-1,2-diphenylethylene (3,4 ',5-Stilbenetriol), ifomula yamangqamuzana. yi-C14H12O3, kanti isisindo samangqamuzana singama-228.25. Ukubonakala kwe-resveratrol ehlanzekile kumhlophe kuya kokukhanya okuphuzi okuyimpushana, ayinaphunga, kunzima ukuncibilika emanzini, kuncibilika kalula kuzincibilikisi eziphilayo ezifana ne-ether, i-chloroform, i-methanol, i-ethanol, i-acetone, i-ethyl acetate, njll., enephuzu lokuncibilika elingu-253 ~ 255°C. Izinga lokushisa le-sublimation lingu-261 ℃. Ingabonakala ibomvu nezixazululo ze-alkaline ezifana namanzi e-ammonia, futhi ingasabela nge-ferric chloride-potassium ferricyanide ukuze ithuthukise umbala. Lesi sakhiwo singasetshenziswa ukukhomba i-resveratrol.
I-resveratrol yemvelo inezakhiwo ezimbili, i-cis ne-trans. Itholakala kakhulu ekuguqulweni kwemvelo. Lezi zakhiwo ezimbili zingahlanganiswa ne-glucose ngokulandelanayo ukuze zenze i-cis ne-trans resveratrol glycosides. I-cis- ne-trans-resveratrol glycosides ingakhulula i-resveratrol ngaphansi kwesenzo se-glycosidase emathunjini. Ngaphansi kokukhanya kwe-UV, i-trans-resveratrol ingaguqulelwa ku-cis-isomer.
I-Resveratrol ikhiqiza i-fluorescence ngaphansi kokukhanya kwe-ultraviolet okungu-366nm. UJeandet et al. inqume izici ze-UV spectral ze-resveratrol kanye neziqongo zokumunca kwayo kwe-infrared ku-2800~3500cm (OH bond) kanye no-965cm (i-transform ye-double bond). Ukuhlola kubonise ukuthi i-trans-resveratrol izinzile ngisho noma ishiywe izinyanga ezimbalwa, ngaphandle kwamabhafa e-pH ephezulu, inqobo nje uma iqhelelene ngokuphelele nokukhanya.
I-Resveratrol ine-bioavailability ephansi kakhulu emzimbeni, ngocwaningo olubonisa ukuthi i-bioavailability ye-resveratrol metabolites emathunjini amancane nesibindi cishe i-1%. I-Resveratrol igaywa ngokushesha ezilwaneni futhi ifinyelela inani layo eliphakeme ku-plasma kungakapheli imizuzu emi-5. Ucwaningo lwe-Metabolism ezilwaneni zithole ukuthi i-resveratrol igaywe kakhulu ezilwaneni ezincelisayo njengamagundane, izingulube, izinja, njll. ngendlela ye-resveratrol sulfate esterification kanye nemikhiqizo ye-glucuronidation. Ucwaningo luye lwaqinisekisa ukuthi i-resveratrol isakazwa ngamafomu abophekile ezicutshini ezahlukene zezilwane ezincelisayo, futhi i-resveratrol idonswa kakhulu futhi isatshalaliswe ezingxenyeni ezigcwele igazi elicebile, njengesibindi, izinso, inhliziyo nobuchopho. Ngokucwaninga nge-metabolism ye-resveratrol emzimbeni womuntu, kwatholakala ukuthi ukugcwala kwe-resveratrol ku-plasma yabantu abajwayelekile kukhombisa "isenzakalo esiphakeme esiphindwe kabili" ngemuva kokuphathwa ngomlomo, kodwa akuzange kube khona isenzakalo esinjalo ngemva kokuphathwa kwe-iv (umjovo we-intravenous). ; ukuhlushwa kwe-resveratrol ku-plasma ngemva kokuphathwa ngomlomo Imikhiqizo eyinhloko ye-alcohol metabolism yi-glucuronidation ne-sulfate esterification. Ngemuva kokuthi iziguli ezinomdlavuza we-colorectal zithathe i-resveratrol ngomlomo, ikholoni yesokunxele idonsa kancane kunohlangothi lwesokudla, futhi kutholakala ama-metabolites ayisithupha, i-resveratrol-3-O-glucuronide ne-resveratrol-4'-O-glucuronide. I-Resveratrol sulfate ne-glucuronide compounds njenge-glucuronide, i-resveratrol-3-O-sulfate, ne-resveratrol-4'-O-sulfate.
