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Ukuthengisa okushisayo CAS 52232-67-4 Teriparatide acetate intengo enhle ukulethwa okuphephile ukulethwa kwekhwalithi ephezulu yokuthengisa okushisayo okushisayo nokwaneliseka okuphezulu kwamakhasimende
ukucaciswa komkhiqizo
| Igama Elivamile | I-Teriparatide acetate |
| Inombolo ye-CAS | 52232-67-4 |
| Isisindo samangqamuzana | 4177.77000 |
| I-Molecular Formula | I-C181H291N55O51S2 |
| EINECS | 640-978-1 |
| Ukuzinza | I-Hygroscopic |
| Ukubukeka | impushana |
| Isimo sesitoreji | -20°C |
Ividiyo Yomkhiqizo
Ukusetshenziswa komkhiqizo
I-Teripartite i-agonist ye-PHT, futhi inani layo le-IC50 kumaseli we-HEK293 liyi-2 nM.I-Teripartite ingaxhumanisa i-bone metabolism ngokuvimbela i-osteoblast apoptosis, isebenze amaseli olwelwesi lwamathambo futhi ithuthukise ukuhlukaniswa kwe-osteoblast. Ngokulawula i-adenylate cyclase-cyclic adenosine monophosphate-protein kinase A indlela, ama-PHT-ⅰ ama-receptors angaphezulu kwama-osteoblasts, amaseli olwelwesi lwethambo kanye namaseli e-stromal womnkantsha akhuthazwa ngezikhathi ezithile ukuze akhuthaze ukuhlukaniswa kwama-osteoblasts futhi andise ukuphila kwawo. Khuthaza ukwanda kwemigqa yeseli ye-osteoblast ngokusebenzisa i-phosphate C- cytoplasmic calcium ion-protein kinase Chemibook C indlela yokudlulisa isignali; Ngokuvimbela umsebenzi we-trans-activation we-PPARγ, ukuhlukaniswa kwamaseli e-stromal emigqeni ye-adipocyte kuyancishiswa futhi inani lama-osteoblasts liyakhula. Ukulawulwa okungaqondile kokukhula kwamathambo ngokulawula ama-cytokines, isibonelo, kungenza i-iGF-1 ihlanganise nama-osteoblasts, ngaleyo ndlela ikhuthaze ukwakheka kwamathambo; Indlela yokubonisa i-Wnt ilawula inqubo yokwakheka kwamathambo, ngaleyo ndlela ikhulise ukwakheka kwamathambo.
Ulwazi Lwenkampani
I-Demei Pharmaceutical Technology Co., Ltd.iyibhizinisi eliguqukayo nelisungulayo elisebenza ngokukhethekile ocwaningweni, ekukhiqizeni nasekusabalaliseni izithako zokwenza imithi ezisezingeni eliphezulu nezinhlanganisela zemvelo. Ngokuzibophezela okuqinile ekuthuthukiseni imboni yezemithi yomhlaba wonke, sizinikele ekusizeni ukuthunyelwa kwemikhiqizo yezemithi yamaShayina emhlabeni wonke. Iphothifoliyo yethu yomkhiqizo ebanzi izuze ukuqashelwa ezimakethe ezibalulekile, okuhlanganisa i-UK, iJalimane, i-Australia, i-Netherlands, i-Poland, i-Russia, i-Kazakhstan, i-Philippines, i-Malaysia, i-Singapore, nezinye izifunda eziningi. Samukela izimiso zobuqotho nokungafihli lutho, sibeka kuqala ubudlelwano obuthembekile namakhasimende ethu, siqinisekisa impumelelo efanayo kanye nobudlelwano besikhathi eside.
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