Ngophuhliso oluqhubekayo kunye nokuvuthwa koshishino lweekhemikhali, inkampani yethu iye yaba namava ngakumbi nangakumbi kwindlela ende yokugxila kwizinto ezikrwada zamayeza, kungekuphela nje kulawulo lomgangatho wemveliso, kodwa nasekubekeni iliso labasebenzi ngaphambi nasemva kokuthengisa. , kunye nokuqaliswa kwezixhobo zemveliso. Iimfuno ezingqongqo zophuculo kunye nophuculo zenze inkampani yethu ihambela phambili nangaphezulu, ixesha lendawo zabathengi liya liba banzi kwaye liba banzi, kwaye umda weshishini nawo uyanda unyaka nonyaka, kubandakanya uphuhliso kunye nophando lwezixhobo zokuthambisa. Ukongeza, inkampani yethu ngoku inemisebenzi emitsha eqhubekayo malunga nezixhobo ezikrwada zamayeza. Ngoku sakha indawo yokuvelisa ngaphezu kwe-7,000 yeemitha zesikwele ukuze sikhethe ukuveliswa kwe-resveratrol, sizama ukuba ngumvelisi oyintloko we-resveratrol. umthengisi.
Ke yintoni kanye kanye i-resveratrol? Makhe ndikunike intshayelelo emfutshane.
I-Resveratrol (3-4'-5-trihydroxystilbene) i-non-flavonoid polyphenol ikhompawundi igama layo lekhemikhali yi-3,4',5-trihydroxy-1,2-diphenylethylene (3,4 ',5-Stilbenetriol), i-molecular formula. yiC14H12O3, kwaye ubunzima bemolekyuli yi-228.25. Inkangeleko ye-resveratrol ecocekileyo imhlophe ukuya kumgubo omthubi okhanyayo, ayinavumba, kunzima ukuyinyibilika emanzini, inyibilika ngokulula kwizinyibilikisi zezinto eziphilayo ezifana ne-ether, i-chloroform, i-methanol, i-ethanol, i-acetone, i-ethyl acetate, njl., enendawo yokunyibilika ye-253 ~ ~ ~ ~ 255°C. Ubushushu be-sublimation yi-261℃. Ingabonakala ibomvu ngezisombululo zealkaline ezifana namanzi ammonia, kwaye inokusabela ngeferric chloride-potassium ferricyanide ukuphuhlisa umbala. Le propati ingasetyenziselwa ukuchonga i-resveratrol.
I-resveratrol yendalo inezakhiwo ezimbini, i-cis kunye ne-trans. Ibakho ikakhulu kutshintsho kwindalo. Izakhiwo ezibini zinokudibaniswa ne-glucose ngokulandelanayo ukwenza i-cis kunye ne-trans resveratrol glycosides. I-cis- kunye ne-trans-resveratrol glycosides inokukhulula i-resveratrol phantsi kwesenzo se-glycosidases emathunjini. Ngaphantsi kokukhanya kwe-UV, i-trans-resveratrol inokuguqulwa ibe yi-cis-isomer.
I-Resveratrol ivelisa i-fluorescence phantsi kwe-366nm ukukhanya kwe-ultraviolet. UJeandet et al. inqume iimpawu ze-UV ze-spectral ze-resveratrol kunye ne-infrared absorption peaks kwi-2800 ~ 3500cm (OH bond) kunye ne-965cm (i-transform ye-double bond). Iimvavanyo zibonise ukuba i-trans-resveratrol izinzile nokuba ishiywe kwiinyanga ezininzi, ngaphandle kwee-buffers eziphezulu ze-pH, nje ukuba ihluke ngokupheleleyo ekukhanyeni.
I-Resveratrol ine-bioavailability ephantsi kakhulu emzimbeni, kunye nezifundo ezibonisa ukuba i-bioavailability ye-resveratrol metabolites emathunjini amancinci kunye nesibindi malunga ne-1%. I-Resveratrol i-metabolized ngokukhawuleza kwizilwanyana kwaye ifikelela kwixabiso layo eliphezulu kwi-plasma ngaphakathi kwemizuzu ye-5. Izifundo ze-Metabolism kwizilwanyana zifumene ukuba i-resveratrol i-metabolized ikakhulu kwizilwanyana ezincelisayo ezifana neegundane, iihagu, izinja, njl njl ngendlela ye-resveratrol sulfate esterification kunye neemveliso ze-glucuronidation. Uphononongo luqinisekisile ukuba i-resveratrol isasazwa kwiifom ezibophelelweyo kwizicubu ezahlukeneyo zezilwanyana ezincelisayo, kwaye i-resveratrol ifakwe ngakumbi kwaye isasazwe kwizitho ezinegazi elicebileyo, njengesibindi, izintso, intliziyo kunye nengqondo. Ngophando malunga ne-metabolism ye-resveratrol emzimbeni womntu, kwafunyaniswa ukuba ukuxinwa kwe-resveratrol kwi-plasma yabantu abaqhelekileyo kubonisa "into ephindwe kabini" emva kokulawulwa komlomo, kodwa kwakungekho nto enjalo emva kokulawulwa kwe-iv (inaliti ye-intravenous) ; Ukuxinwa kwe-resveratrol kwi-plasma emva kokulawulwa komlomo Iimveliso eziphambili ze-alcohol metabolism yi-glucuronidation kunye ne-sulfate esterification. Emva kokuba izigulane ezinomdlavuza we-colorectal zithatha i-resveratrol ngomlomo, ikholoni yekhohlo ithatha ngaphantsi kwecala lasekunene, kwaye i-metabolites ezintandathu, i-resveratrol-3-O-glucuronide kunye ne-resveratrol-4'-O-glucuronide, ifunyenwe. I-Resveratrol sulfate kunye ne-glucuronide compounds ezifana ne-glucuronide, i-resveratrol-3-O-sulfate, kunye ne-resveratrol-4'-O-sulfate.
