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Ukuthengisa okushushu CAS 52232-67-4 Teriparatide acetate ixabiso elilungileyo ukuhanjiswa okukhuselekileyo komgangatho ophezulu wentengiso eshushu isitokhwe kunye nokwaneliseka okuphezulu kwabathengi.
ukucaciswa kwemveliso
| Igama eliqhelekileyo | I-Teriparatide acetate |
| Inombolo yeCAS | 52232-67-4 |
| Ubunzima beMolekyuli | 4177.77000 |
| Ifomula yeemolekyuli | C181H291N55O51S2 |
| EINECS | 640-978-1 |
| Uzinzo | Hygroscopic |
| Imbonakalo | umgubo |
| Imeko yokugcina | -20°C |
Ividiyo yeMveliso
Ukusetyenziswa kweMveliso
I-Teripartite i-agonist ye-PHT, kunye nexabiso layo le-IC50 kwiiseli ze-HEK293 yi-2 nM.Teripartite inokulungelelanisa i-metabolism yamathambo ngokuvimbela i-osteoblast apoptosis, isebenze iiseli zamathambo kunye nokuphucula ukuhlukana kwe-osteoblast. Ngokulawula i-adenylate cyclase-cyclic adenosine monophosphate-protein kinase A pathway, i-PHT-ⅰ i-receptors kumphezulu we-osteoblasts, iiseli ze-bone lining kunye neeseli ze-stromal zomongo zivuselelwa ngokukhawuleza ukukhuthaza ukuhlukana kwe-osteoblasts kunye nokwandisa ubomi babo. Ukukhuthaza ukwanda kwemigca yeeseli ze-osteoblast ngokusebenzisa i-phosphate C- cytoplasmic calcium ion-protein kinase I-Chemibook C indlela yokudlulisa uphawu; Ngokuthintela umsebenzi we-trans-activation we-PPARγ, ukuhlukana kweeseli ze-stromal kwimigca ye-adipocyte kuyancipha kwaye inani le-osteoblasts liyanda. Ukulawulwa ngokungathanga ngqo kokukhula kwamathambo ngokulawula i-cytokines, umzekelo, inokwenza i-iGF-1 idibanise ne-osteoblasts, ngaloo ndlela ikhuthaza ukubunjwa kwamathambo; Indlela yokubonakalisa iWnt ilawula inkqubo yokwakheka kwamathambo, ngaloo ndlela inyusa ukubunjwa kwamathambo.
Ulwazi lweNkampani
I-Demei Pharmaceutical Technology Co., Ltd.lishishini eliguquguqukayo neliyintshayo eligxile kuphando, ukuvelisa, kunye nokusasazwa kwezithako zamayeza ezikumgangatho ophezulu kunye neekhompawundi eziphilayo. Ngokuzibophelela ngokuqinileyo ekuqhubeleni phambili ishishini loxubo mayeza lehlabathi, sizinikele ekuququzeleleni ukuthunyelwa kwemveliso yamayeza eTshayina kwihlabathi liphela. Ipotfoliyo yethu yemveliso ebanzi iye yafumana ukuqondwa kwiimarike eziphambili, kuquka i-UK, iJamani, i-Australia, iNetherlands, iPoland, iRashiya, iKazakhstan, iiPhilippines, iMalaysia, iSingapore, kunye neminye imimandla emininzi. Ukwamkela imigaqo yemfezeko kunye nokungafihli, sibeka phambili ukwakha ubudlelwane obuthembekileyo kunye nabathengi bethu, siqinisekisa impumelelo efanayo kunye nobudlelwane bexesha elide.
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