Ukuthengisa okushushu CAS 16941-32-5 IGlucagon enobunyulu obuphezulu obuphezulu bexabiso elishushu elishushu lokuthengisa isitokhwe emnyango ukuya emnyango kunye nokwaneliseka okuphezulu kwabathengi.

Umsebenzi ophambili weglucagon kukukhuthaza ukubola kwe-glycogen kunye nokuvelisa i-glucose ukunyusa iswekile yegazi; Okwesibini, umgangatho we-cyclic adenosine monophosphate (cAMP) unokunyuswa nge-adenylate cyclase, ngaloo ndlela isebenze iprotein kinase, isebenze i-lipase kwi-adipose tissue kunye nokukhuthaza i-lipolysis. Yenza inkqubo ye-myocardial adenylate cyclase isebenze, ikhuthaze umsebenzi we-myocardial phosphorylase, ikhulise ukuqokelelwa kwe-calcium kwi-myocardium, ngaloo ndlela iphucula i-contractility ye-myocardial, inyusa ukuphuma kwentliziyo kunye nokunyusa uxinzelelo lwegazi; Iyakwazi nokukhuthaza ukukhuselwa kwe-islet Chemicalbook, i-somatostatin, i-thyroxine kunye ne-calcitonin; Ukukhuthaza ukukhululwa kwe-catecholamine kwi-nerve evelwano kunye neeseli ze-chromaffin. I-Glucagon, i-insulin kunye ne-somatostatin zilawulana ukuze zigcine iswekile yegazi kwindawo eqhelekileyo. Ukukhuselwa kweglucagon kuhambelana ngokungafaniyo nokuxinana kweglucose yegazi, kwaye kwangaxeshanye, ukukhuselwa kweglucagon kukwachatshazelwa zii-amino acids, i-plasma free fatty content, i-α -adrenergic receptor stimulator (norepinephrine), i-auxin release hormone inhibitory and njalo njalo.

IGlucagon yihomoni ye-polypeptide yekhonkco enye eyenziwe yaza yakhutshelwa ziiseli ze-islet α2. Ngumchasi we-physiological we-insulin. Impembelelo kwi-metabolism ifana ne-adrenaline, kwaye inemisebenzi elandelayo: 1. Umsebenzi wokunyusa iswekile yegazi: inokwenza i-phosphorylase isebenze kwisibindi, ikhuthaze ukubola kwesibindi se-glycogen kunye ne-heterogenesis ye-glycogen, kwaye iphakamise. iswekile yegazi. 2. Isiphumo esihle se-inotropic: inokunyusa umxholo we-cAMP ye-intracellular, iphucule i-contractility ye-myocardial, inyuse imveliso yenhliziyo kunye nomsebenzi we-stroke. Isiphumo sayo esihle se-inotropic sisenokwenziwa emva kokuba i-cardiac glycoside eyaneleyo isetyenziswe, kwaye ayivalwanga yipropranolol. Nangona inokunyusa izinga lentliziyo kunye noxinzelelo lwegazi, ayiyi kubangela i-arrhythmia. Indlela yokusebenza ihamba ngolu hlobo lulandelayo: ① Ukusebenza kwe-adenylate cyclase kwenza i-adenosine triphosphate itshintshe ibe yi-cyclic adenosine monophosphate, ephucula ukukhontraktha kwe-myocardial ye-Chemicalbook; ② Ukukhuthaza ukubola kwesibindi se-glycogen kunye nokunyusa izinga leswekile yegazi; ③ Ukukhuthaza ukukhutshwa kwe-insulin, ukuphucula ukusetyenziswa kwe-glucose nge-myocardium, kunye nokukhuthaza i-anaerobic glycolysis ye-myocardium, ngaloo ndlela kuphuculwe amandla e-metabolism ye-myocardium. Idityaniswe ne-digitalis cardiac glycosides, inokunyusa isiphumo sokunyanga. 3. Impembelelo kwizintso: i-dilate imithambo yegazi ye-renal, iphucula ukuhamba kwegazi le-renal kunye nokukhuthaza ukukhutshwa kwe-sodium, i-potassium kunye ne-calcium. 4. Impembelelo kwindlela yokugaya ukutya: Inokubangela ukukhululeka kwemisipha yesisu kunye ne-duodenum, amathumbu amancinci kunye nekholoni, inhibit peristalsis yesisu, amathumbu amancinci kunye nekholoni, kunye nokunyusa ukukhuselwa kwe-bile kunye ne-intestinal fluid. 5. Impembelelo kwi-system secretory: Gcoba i-adrenal medulla kwaye ukhuthaze ukukhululwa kwe-catecholamines. Inokukhuthaza ukukhuselwa kwe-insulin, ihomoni ye-thyroid, i-calcitonin kunye nehomoni yokukhula.