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I-CAS 69440-99-9 i-Thymalfasin enexabiso eliphakamileyo elithengisa umgangatho ophezulu wokwaneliseka kwabathengi kunye nokuhanjiswa ngokukhawuleza okukhuselekileyo.
ukucaciswa kwemveliso
| Igama eliqhelekileyo | Thymalfasin |
| Inombolo yeCAS | 69440-99-9 |
| Ubunzima beMolekyuli | 3108.275 |
| Ukuxinana | 1.4±0.1 g/cm3 |
| Indawo yokubilisa | 2899.7±65.0 °C kwi-760 mmHg |
| Ifomula yeemolekyuli | C129H215N33O55 |
| EINECS | 1592732-453-0 |
| Indawo yokuflasha | 1707.5±34.3 °C |
| IMisa ngqo | 3106.504150 |
| Imbonakalo | umgubo |
| Imeko yokugcina | -20°C |
Ividiyo yeMveliso
Ukusetyenziswa kweMveliso
I-Thymalfasin luhlobo lweprotheyini kunye nehomoni ye-polypeptide enomsebenzi wokuphucula umzimba, oveliswa ziiseli ze-epithelial kwi-cortex engaphezulu kunye ne-medulla ye-thymus. Yipolypeptide eneasidi eyenziwe ngama-amino acid angama-28. Ngumlawuli wempendulo yebhayoloji enoluhlu olubanzi lwemisebenzi yebhayoloji. Isetyenziswa ikakhulu kunyango lwe-immunodeficiency, usulelo lwentsholongwane kunye namathumba ekliniki. Lichiza lokuqala kunyango lwe-hepatitis B, kwaye linokusetyenziswa njengechiza elincedisayo kwizitofu zokugonya. Umphumo wonyango uyamangalisa. Inenzuzo yomsebenzi ophezulu, ityhefu encinci kunye nemiphumo emibi kunye nezibonakaliso ezibanzi. I-Thymalfasin inokunyusa ukusebenza kweeseli ze-P, ikhuthaze imveliso ye-lymphocyte, ilawule umlinganiselo we-P cell subsets, ukwahlukana kweeseli ze-U kunye nokuveliswa kwe-antibody, ikhuthaze ukuveliswa kweminye i-antiviral lymphatic factor kunye ne-macrophages, iphucule i-phagocytosis, kwaye iphucule umsebenzi we-cell immune system. izigulane ithumba. Iyakwazi nokususa ibhaktheriya, umngundo kunye neentsholongwane emzimbeni. Indlela entsha ye-thymic isetyenziswe kwinkqubo ye-nervous kunye ne-endothelium ejikeleze i-endothelium, edlala indima ekulawuleni ukuhanjiswa kwe-synaptic ye-hippocampal neurons. I-Thymalfasin ichaphazela ukuhanjiswa kwe-excitatory synapses kunye ne-nervous system, kwaye ingasetyenziselwa ukukhusela i-neurotoxicity ebangelwa yi-chemotherapy kunye nolunye unyango lwe-anticancer kwizigulana zomhlaza. I-Thymalfasin inomsebenzi wolawulo lwemfuza, enokuthi ibangele i-kinase cascade genes, up-regulate cytokine genes kunye ne-immune regulation regulation genes. Isiphumo solawulo oluphezulu lwe-thymalfasin kwijeni ye-receptor enjenge-Toil ibonisa ukuba i-thymalfasin inokuvuselela iiseli ezibonisa i-antigen. Indima ye-thymidine ekukhuleni kweeseli ze-immune ibonakala kwi-up-regulation ye-stem cell growth factor kunye ne-hematopoietic protein gene expression.
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