I-CAS 204656-20-2 ILiraglutide yaseTshayina intengiso egqwesileyo yefektri ngokuthe ngqo uKhuseleko oluPhezulu loKhuseleko oluPhezulu Ukuhanjiswa okuphezulu Umgangatho ofanelekileyo ixabiso eliphakamileyo lamaxabiso aphezulu ukwaneliseka Ukuhanjiswa okukhawulezayo

I-Liraglutide, i-lipopeptide kunye ne-polypeptide, yi-analogue ye-GLP-1 yomntu apho intsalela ye-lysine kwindawo ye-27 itshintshwa yi-arginine kunye neqela le-hexadecanoyl elidityaniswe kwi-lysine eseleyo nge-spacer ye-glutamic acid. Isetyenziselwa kunye nokutya kunye nokuzivocavoca ukuphucula ulawulo lwe-glycemic kubantu abadala abane-type 2 yesifo sikashukela. I-Liraglutide isebenza njenge-glucagon-like peptide-1 receptor agonist kwaye isebenza njenge-neuroprotective agent.

Qhagamshelana nathi

iinkcukacha zemveliso

ukupakisha & ukuhambisa

Ingcaciso yeMveliso

I-Liraglutide yi-GLP-1 (1-37) iguqulwe e-Ly: iqela le-amino li-acylated kunye ne-(N-hexadecanoyl) glutam- -yl moiety ebophelela ngokungekho ngqiqweni kodwa ngokungqongqo kwi-albumin ye-serum yomntu. (Kwakhona, i-Lys is conservatively replaced with Arg.) Olu tshintsho lubonelela ngeserum eyandisiweyo kakhulu i-t1?2 ye-10 ukuya kwiiyure ezili-15 emva kolawulo lwe-sc(0.6–1.8 mg), ivumela idosi kanye ngemini.Liraglutide (Victoza, Novo Nordisk) ilindele ukwamkelwa yi-FDA, EMEA, kunye neKoˉ roˉ -shoˉ (eJapan).

ividiyo yemveliso

Isicelo seMveliso

I-Liraglutide luhlobo olutsha lwechiza le-hypoglycemic eyenza i-AMP-activated protein kinase ngaloo ndlela ikhulise uvakalelo lwe-insulin. Ayinayo nje impembelelo enkulu ye-hypoglycemic, kodwa inemisebenzi yokulahleka kwesisindo, ukunciphisa uxinzelelo lwegazi, kunye nokuphuculwa kweprofayili ye-lipid yegazi.

I-Liraglutide, i-glucagon yomntu efana ne-peptide-1 (GLP-1) ye-receptor agonist, iyacotha ukuphuma kwesisu, inyusa ukuhlutha, kwaye iyanciphisa ukutya kwesigulana, ngelixa inciphisa umnqweno wengqondo wokutya kunye nokuvumela umzimba ukuba Ukonyuka kwenkcitho yamandla kudlala indima kubunzima. ilahleko; ikhusela isibindi ekuveliseni i-glucose eninzi kwaye ikhuthaza i-pancreas ukuvelisa i-insulin eninzi ukunciphisa iswekile yegazi; Ukongeza, i-liraglutide ikwanezibonelelo zentliziyo kunye nokukhuselwa kwezintso.

ukucaciswa kwemveliso

Igama eliqhelekileyo	ILiraglutide
Inombolo yeCAS	204656-20-2
Ifomula yeemolekyuli	C172H265N43O51
Ubunzima beMolekyuli	3751.20000
PSA	1513.76000
LogP	6.12960
EINECS	810-818-7