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I-CAS 1451-83-8 I-China igqwesileyo umenzi wemveliso ngokuthe ngqo kwintengiso ephezulu Umgangatho oKhawuleza Ukuhanjiswa kweendleko eziphezulu ulwaneliseko Ukuhanjiswa ngenqanawe ngexabiso elifanelekileyo Ukucoceka okuphezulu
Ingcaciso yeMveliso
I-Pregabalin (i-Lyrica), i-derivative ye-GABA ehambelana ngokusondeleyo ne-gabapentin, iye yafumana uphando olubanzi ngokusebenza kwayo ekuphatheni iimeko ezifana ne-generalized disorder disorder (GAD), i-fibromyalgia, intlungu ye-neuropathic, kunye nokuxhuzula okuyingxenye. Kubonakala ngathi kunempembelelo ejoliswe ngakumbi kwi-a2-δ subunit yeziteshi ze-calcium kwingqondo xa kuthelekiswa ne-gabapentin. I-Pregabalin inikwe imvume ye-FDA ekupheleni kwe-2004 yonyango lwentlungu ye-neuropathic kunye ne-epilepsy. Kwi-2008, yaba liyeza lokuqala elivunyiweyo kulawulo lwe-fibromyalgia. Nangona i-pregabalin yamkelwa unyango lwe-GAD kwi-European Union kwi-2006, ayikafumani imvume ye-FDA ye-GAD e-United States njengexesha lokubhala.
ividiyo yemveliso
Isicelo seMveliso
S-Enantiomer yePregabalin. I-analogue ye-GABA esetyenziswa njenge-anticonvulsant. I-Anxiolytic analgesic esetyenziselwa ukunyanga intlungu ye-peripheral neuropathic kunye ne-fibromyalgia.
I-Pregabalin lichiza le-anticonvulsant elisetyenziselwa iintlungu ze-neuropathic, njengonyango olongezelelweyo lokuxhuzula inxalenye, kwayejikelele ukuphazamiseka kokuxhalaba. Yayiyilwe njengendlalifa enamandla ngakumbi kwi-gabapentin. I-Pregabalin ithengiswa nguPfizer phantsi kwegama lokuthengisa
ukucaciswa kwemveliso
| Igama eliqhelekileyo | Pregabalin |
| Inombolo yeCAS | 148553-50-8 |
| Ukuxinana | 1.0±0.1 g/cm3 |
| Indawo yokubilisa | 274.0±23.0 °C kwi-760 mmHg |
| Ifomula yeemolekyuli | C8H17NO2 |
| Ubunzima beMolekyuli | 159.226 |
PSA | 63.32000 |
LogP | 1.12 |
EINECS | 604-639-1 |
Uxinzelelo lomphunga | 0.0±1.2 mmHg ku-25°C |
Isalathiso seRefraction | 1.465 |
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