Ka nts'etsopele le kholo e tsoelang pele ea indasteri ea lik'hemik'hale, k'hamphani ea rona e se e bile le boiphihlelo le ho feta tseleng e telele ea ho tsepamisa maikutlo ho lisebelisoa tse tala tsa meriana, eseng feela taolong ea boleng ba sehlahisoa, empa hape le taolong ea basebetsi pele le kamora thekiso. , le kenyelletso ea thepa ea lihlahisoa. Litlhoko tse tiileng tsa ho ntlafatsa le ho ntlafatsa li entse hore k'hamphani ea rona e tsoele pele le ho feta, sebaka sa libaka tsa bareki se ntse se hola, 'me sebaka sa khoebo se ntse se hola selemo le selemo, ho kenyelletsa le nts'etsopele le lipatlisiso tsa lisebelisoa tse tala tsa litlolo. Ntle le moo, k'hamphani ea rona hajoale e na le mesebetsi e mecha e ntseng e tsoela pele mabapi le thepa e tala ea meriana. Hona joale re haha sebaka sa tlhahiso ea sebaka se fetang lisekoere-mithara tse 7,000 ho ikhethela tlhahiso ea resveratrol, re ikitlaelletsa ho ba mohlahisi ea ka sehloohong oa resveratrol. mofani oa thepa.
Joale resveratrol hantle ke eng? E-re ke u fe kenyelletso e khutšoanyane.
Resveratrol (3-4'-5-trihydroxystilbene) ke motsoako o se nang flavonoid polyphenol oo lebitso la oona la lik'hemik'hale e leng 3,4',5-trihydroxy-1,2-diphenylethylene (3,4 ',5-Stilbenetriol), mokhoa oa molek'hule. ke C14H12O3, 'me boima ba molek'hule ke 228.25. Ponahalo ea resveratrol e hloekileng e tšoeu ho isa ho phofo e mosehla, ha e na monko, e thata ho qhibiliha ka metsing, e qhibiliha habonolo ka har'a lihlapolli tse kang ether, chloroform, methanol, ethanol, acetone, ethyl acetate, joalo-joalo, e nang le ntlha e qhibilihang ea 253 ~ ~ ~ 255°C. Mocheso oa sublimation ke 261 ℃. E ka bonahala e le khubelu ka litharollo tsa alkaline joalo ka metsi a ammonia, 'me e ka arabela ka ferric chloride-potassium ferricyanide ho hlahisa mmala. Thepa ena e ka sebelisoa ho khetholla resveratrol.
Resveratrol ea tlhaho e na le mehaho e 'meli, cis le trans. Haholo-holo e teng ho trans conformation ka tlhaho. Mehaho e 'meli e ka kopanngoa le tsoekere ka ho latellana ho etsa cis le trans resveratrol glycosides. Cis- and trans-resveratrol glycosides e ka lokolla resveratrol tlas'a ketso ea glycosidase ka maleng. Tlas'a mahlaseli a khanya a UV, trans-resveratrol e ka fetoloa cis-isomer.
Resveratrol e hlahisa fluorescence tlas'a leseli la ultraviolet la 366nm. Jeandet et al. e ile ea etsa qeto ea litšoaneleho tsa mahlaseli tsa UV tsa resveratrol le litlhōrō tsa eona tsa ho monya ha infrared ho 2800 ~ 3500cm (OH bond) le 965cm (trans form of double bond). Liteko li bontšitse hore trans-resveratrol e tsitsitse esita le haeba e siiloe ka likhoeli tse 'maloa, ntle le li-buffers tse phahameng tsa pH, hafeela e arohane ka ho feletseng le leseli.
Resveratrol e na le bioavailability e batlang e le tlase 'meleng, ka lithuto tse bonts'ang hore bioavailability ea metabolites ea resveratrol ka maleng a manyane le sebeteng e batla e le 1%. Resveratrol e kenngoa ka potlako liphoofolong 'me e fihla tlhōrōng ea eona ho plasma nakong ea metsotso e 5. Lithuto tsa metabolism ea liphoofolo li fumane hore resveratrol e sebelisoa haholo ho liphoofolo tse anyesang tse kang likhoto, likolobe, lintja, joalo-joalo ka mokhoa oa resveratrol sulfate esterification le lihlahisoa tsa glucuronidation. Liphuputso li netefalitse hore resveratrol e ajoa ka mefuta e tlamahantsoeng ho li-tissue tse fapaneng tsa liphoofolo tse anyesang, 'me resveratrol e kenella haholoanyane le ho ajoa lithong tse nang le mali a mangata, joalo ka sebete, liphio, pelo le boko. Ka lipatlisiso tse mabapi le metabolism ea resveratrol 'meleng oa motho, ho ile ha fumanoa hore khatello ea resveratrol ka plasma ea batho ba tloaelehileng e bontša "ketsahalo e phahameng habeli" ka mor'a tsamaiso ea molomo, empa ha hoa ka ha e-ba le ketsahalo e joalo ka mor'a tsamaiso ea iv (ente e kenang methapong) ; khatello ea resveratrol ka plasma ka mor'a tsamaiso ea molomo Lihlahisoa tse ka sehloohong tsa metabolism ea joala ke glucuronidation le sulfate esterification. Ka mor'a hore bakuli ba nang le kankere ea mala ba nke resveratrol ka molomo, kolone e letšehali e nka ka tlaase ho lehlakoreng le letona, 'me ho fumanoa metabolite tse tšeletseng, resveratrol-3-O-glucuronide le resveratrol-4'-O-glucuronide. Resveratrol sulfate le glucuronide metsoako e kang glucuronide, resveratrol-3-O-sulfate, le resveratrol-4'-O-sulfate.
