0102
Mabapi le CAS 103-90-2 Acetaminophen
2024-05-10 09:37:28
| Sebaka se qhibilihang | 168-172 °C(hote.) |
| Ntho e belang | 273.17°C (khakanyo e boima) |
| tekano | 1,293 g/cm3 |
| khatello ea mouoane | 0.008Pa ho 25 ℃ |
| index ea refractive | 1.5810 (khakanyo e fosahetseng) |
| Fp | 11 °C |
| mocheso oa polokelo. | Boemo bo sa tsitsang, Mocheso oa Kamore |
| ho qhibiliha | ethanol: soluble0.5M, e hlakileng, ha e na mebala |
| pka | 9.86±0.13(E boletsoeng esale pele) |
| sebopeho | Likristale kapa phofo ea Crystalline |
| mmala | Bosoeu |
Tlhaloso:
Acetaminophen, eo hape e tsejoang e le paracetamol, ke motsoako oa lik'hemik'hale o nang le foromo ea molek'hule C8H9NO2. Ke meriana e oelang tlas'a sehlopha sa li-analgesics (li-pain relievers) le antipyretics (feberu e fokotsang feberu). Ka sebopeho, acetaminophen ke motsoako oa para-aminophenol. Mabapi le thepa ea 'mele, acetaminophen ke phofo e tšoeu ea kristale e qhibilihang hanyane ka metsing. E fumaneha hangata ka mefuta e fapaneng, ho kenyelletsa matlapa, li-capsules le li-suspension tsa metsi, bakeng sa tsamaiso ea molomo.
Lisebelisoa:
Acetaminophen e sebelisoa haholo ho kokobetsa bohloko le ho fokotsa feberu. E tsebahala ka katleho ea eona ea ho kokobetsa bohloko bo fokolang ho isa ho bo itekanetseng, bo kang hlooho e opang, ho opa ha mesifa le ho opa ha meno. Ho fapana le li-nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen ha e na thepa ea bohlokoa ea ho thibela ho ruruha.
Mokhoa o nepahetseng oa ts'ebetso ea acetaminophen ha o utloisisoe ka botlalo, empa ho lumeloa hore o kenyelletsa ho thibela enzyme e bitsoang cyclooxygenase (COX) tsamaisong ea methapo e bohareng. Enzyme ena e ameha tlhahisong ea prostaglandin, e phethang karolo ea ho lemoha bohloko le ho laola mocheso oa 'mele.
Acetaminophen e nkoa e le khetho e sireletsehileng bakeng sa phomolo ea bohloko ho batho ba sa khoneng ho mamella li-NSAID ka lebaka la lintlha tse kang liso tsa ka mpeng kapa mathata a ho tsoa mali.
Lipatlisiso tse amanang:
Lithuto tsa in vitro In vitro, acetaminophen e bakile khetho ea 4.4-fold for COX-2 inhibition (IC50 bakeng sa COX-1, 113.7 μM; IC50 bakeng sa COX-2, 25.8 μM). Ka mor'a tsamaiso ea molomo, boholo ba ex vivo inhibition e ne e le 56% (COX-1) le 83% (COX-2). Likhakanyo tsa acetaminophen plasma li ile tsa lula li le kaholimo ho in vitro IC50 ea COX-2 bonyane lihora tse 5 kamora ho nosetsoa. Litekanyetso tsa ex vivo IC50 tsa acetaminophen (COX-1: 105.2 μM; COX-2: 26.3 μM) li bapisoa hantle le litekanyetso tsa eona tsa in vitro IC50. Ho fapana le maikutlo a fetileng, acetaminophen e thibela COX-2 ho feta 80%, tekanyo e ka bapisoang le lithethefatsi tse khahlanong le ho ruruha (NSAIDs) le COX-2 inhibitors e khethiloeng. Leha ho le joalo, ha ho> 95% COX-1 blockade e 'nile ea amahanngoa le ho thibela mosebetsi oa platelet [1]. Tlhahlobo ea MTT e bontšitse hore acetaminophen (APAP) ka tekanyo ea 50mM haholo (p
Lithuto tsa in vivo: Tsamaiso ea acetaminophen (250 mg / kg, ka molomo) ho litoeba e hlahisitse tšenyo e kholo (p