Ho rekisa ho chesang CAS 16941-32-5 Glucagon e nang le bohloeki bo phahameng ba boleng bo holimo theko e phahameng ea thekiso ea thepa e rekisoang monyako le ntlo le khotsofalo e phahameng ea bareki.

Mosebetsi o ka sehloohong oa glucagon ke ho khothalletsa ho bola ha glycogen le ho hlahisa tsoekere ho phahamisa tsoekere ea mali; Taba ea bobeli, boemo ba cyclic adenosine monophosphate (cAMP) bo ka eketsoa ka adenylate cyclase, ka hona, ho kenya protheine kinase, ho kenya lipase meleng ea adipose le ho khothaletsa lipolysis. Kenya ts'ebetso ea myocardial adenylate cyclase, ho khothaletsa ts'ebetso ea myocardial phosphorylase, ho eketsa ho bokellana ha k'halsiamo ka har'a myocardium, ka ho etsa joalo ho matlafatsa contractility ea myocardial, ho eketsa tlhahiso ea pelo le ho phahamisa khatello ea mali; E ka boela ea khothalletsa secretion ea islet Chemicalbook, somatostatin, thyroxine le calcitonin; Khothaletsa ho lokolloa ha catecholamine ho tsoa ho methapo ea kutlo le lisele tsa chromaffin. Glucagon, insulin le somatostatin lia laolana ho boloka tsoekere ea mali e le maemong a tloaelehileng. Ho ntšoa ha glucagon ho fapana ka tsela e fapaneng le khatello ea tsoekere ea mali, 'me ka nako e ts'oanang, secretion ea glucagon e boetse e angoa ke li-amino acid, plasma-free fatty acid content, α -adrenergic receptor stimulator (norepinephrine), auxin release inhibitory hormone. joalo-joalo.

Glucagon ke hormone e nang le ketane e le 'ngoe ea polypeptide e entsoeng le ho hlahisoa ke lisele tsa islet α2. Ke mohanyetsi oa fisioloji oa insulin. Tšusumetso ho metabolism e tšoana le ea adrenaline, 'me e na le mesebetsi e latelang: 1. Mosebetsi oa ho phahamisa tsoekere ea mali: e ka kenya tšebetsong phosphorylase sebeteng, ea khothalletsa ho bola ha sebete sa glycogen le heterogenesis ea glycogen, le ho phahamisa tsoekere e maling. 2. Phello e ntle ea inotropic: e ka eketsa dikahare tsa cAMP ka intracellular, ho ntlafatsa contractility ea myocardial, ho eketsa tlhahiso ea pelo le mosebetsi oa stroke. Phello ea eona e ntle ea inotropic e ntse e ka sebelisoa ka mor'a hore cardiac glycoside e lekaneng e sebelisoe, 'me ha e thibeloe ke propranolol. Leha e ka eketsa lebelo la pelo le khatello ea mali, e ke ke ea baka arrhythmia. Mochini ona o tjena: ① Ts'ebetso ea adenylate cyclase e etsa hore adenosine triphosphate e fetohe cyclic adenosine monophosphate, e ntlafatsang tumellano ea myocardial ea Chemicalbook; ② Khothalletsa ho bola ha sebete sa glycogen le ho phahamisa boemo ba tsoekere maling; ③ Khothaletsa tokollo ea insulin, ho ntlafatsa ts'ebeliso ea tsoekere ka myocardium, le ho khothaletsa anaerobic glycolysis ea myocardium, ka hona ho ntlafatsa metabolism ea matla ea myocardium. Ha e kopantsoe le digitalis cardiac glycosides, e ka eketsa phello ea pholiso. 3. Phello ea liphio: fokotsa methapo ea mali ea renal, ho ntlafatsa phallo ea mali ea renal le ho khothalletsa ho tsoa ha sodium, potasiamo le calcium. 4. Phello tsamaisong ea tšilo ea lijo: E ka etsa hore mesifa e boreleli e phutholohe ea mala le duodenum, mala a manyenyane le colon, e thibela peristalsis ea mpa, mala a manyenyane le colon, le ho eketsa secretion ea bile le mala a mala. 5. Phello tsamaisong ea sekhukhu: Thabisa adrenal medulla le ho khothalletsa ho lokolloa ha catecholamines. E ka boela ea khothalletsa secretion ea insulin, hormone ea qoqotho, calcitonin le hormone ea ho hōla.