Iyada oo horumarinta joogtada ah iyo qaan-gaarnimada warshadaha kiimikada, shirkadeena waxay noqotay mid aad u badan oo khibrad u leh jidka dheer ee diiradda saaraya alaabta ceeriin ee dawooyinka, ma aha oo kaliya xakamaynta tayada alaabta, laakiin sidoo kale kormeerka shaqaalaha ka hor iyo ka dib iibka , iyo soo bandhigida qalabka alaabta. Shuruudaha adag ee cusboonaysiinta iyo cusboonaysiinta ayaa ka dhigay shirkadeena inay sii socoto oo ay sii socoto, baaxadda aagagga macaamiisha ayaa sii kordhaya oo sii kordhaya, baaxadda ganacsiguna sidoo kale way sii kordhaysaa sannadba sanadka ka dambeeya, oo ay ku jiraan horumarinta iyo cilmi-baarista alaabta ceeriin ee la isku qurxiyo. Intaa waxaa dheer, shirkadeena hadda waxay haysaa hawlo cusub oo ku saabsan alaabta ceeriin ee dawooyinka. Waxaan hadda dhisaynaa aag wax-soo-saar oo ka badan 7,000 mitir oo laba jibbaaran si aan ugu takhasusno soo-saarka Resveratrol, annagoo ku dadaaleyno inaan noqonno soo-saaraha ugu weyn ee resveratrol. alaab-qeybiye.
Haddaba waa maxay dhabta ah resveratrol? Aan ku siiyo hordhac kooban.
Resveratrol (3-4'-5-trihydroxystilbene) waa polyphenol non-flavonoid ah oo magaciisu yahay 3,4',5-trihydroxy-1,2-diphenylethylene (3,4',5-Stilbenetriol), qaacidada kelli waa C14H12O3, iyo miisaanka kelli waa 228.25. Muuqaalka resveratrol saafi ah waa caddaan ilaa budo huruud ah, ur aan lahayn, ay adagtahay in lagu milmo biyaha, si fudud ugu milmi kara dareeraha organic sida ether, chloroform, methanol, ethanol, acetone, ethyl acetate, iwm, oo leh dhibic dhalaalaysa 253 ~ 255°C. Heerkulka sublimation waa 261 ℃. Waxay u muuqan kartaa casaan leh xalalka alkaline sida biyaha ammonia, waxayna ka falcelin kartaa ferric chloride-potassium ferricyanide si ay u yeelato midab. Gurigan waxaa loo isticmaali karaa in lagu aqoonsado resveratrol.
Resveratrol dabiiciga ah wuxuu leeyahay laba qaab-dhismeed, cis iyo trans. Waxay inta badan ku jirtaa is beddelka dabeecadda. Labada qaab waxaa lagu dari karaa gulukoos siday u kala horreeyaan si ay u sameeyaan cis iyo trans resveratrol glycosides. Cis- iyo trans-resveratrol glycosides waxay sii dayn karaan resveratrol hoos yimaada ficilka glycosidases ee xiidmaha. Marka la eego shucaaca UV, trans-resveratrol waxa loo rogi karaa cis-isomer.
Resveratrol waxay soo saartaa fluorescence ka hooseeya 366nm ultraviolet light. Jeandet iyo al. waxay go'aamisay sifooyinka UV ee resveratrol iyo nuugista infrared ee ugu sarreysa 2800 ~ 3500cm (OH bond) iyo 965cm (qaabka trans of bond double). Tijaabooyinku waxay muujiyeen in trans-resveratrol ay xasilloon tahay xitaa haddii ay ka tagto dhowr bilood, marka laga reebo kaydinta pH-ga sare, ilaa iyo inta ay gebi ahaanba ka go'an tahay iftiinka.
Resveratrol waxay leedahay bioavailability aad u hooseeya oo jirka ah, iyada oo daraasado muujinaya in bioavailability ee dheef-shiid kiimikaadka resveratrol ee xiidmaha yar iyo beerka ay tahay ku dhawaad 1%. Resveratrol si degdeg ah ayey u dheefi kartaa xayawaanka waxayna ku gaartaa qiimihiisii ugu sarreeyay balaasmaha 5 daqiiqo gudahood. Daraasadaha dheef-shiid kiimikaadka ee xayawaanka ayaa lagu ogaaday in resveratrol ay inta badan metabolized ee naasleyda sida jiirka, doofaarka, eyda, iwm. ee qaabka resveratrol sulfate esterification iyo alaabta glucuronidation. Daraasaduhu waxay xaqiijiyeen in resveratrol loo qaybiyo qaabab xidhxidhan oo loo qaybiyo unugyo kala duwan oo naasley ah, iyo resveratrol waxa ay aad u nuugtaa oo u qaybisaa xubnaha dhiiga qaniga ku ah, sida beerka, kelyaha, wadnaha iyo maskaxda. Iyadoo cilmi baaris lagu sameeyay dheef-shiid kiimikaadka resveratrol ee jirka bini'aadamka, waxaa la ogaaday in fiirsashada resveratrol ee plasma ee bini'aadamka caadiga ah ay muujisay "dhacdo laba jibaaran" ka dib maamulka afka, laakiin ma jirin dhacdo noocaas ah ka dib maamulka iv (mudidda xididka). ; fiirsashada resveratrol ee plasma ka dib maamulka afka Alaabooyinka ugu muhiimsan ee dheef-shiid kiimikaadka khamriga waa glucuronidation iyo sulfate esterification. Ka dib marka bukaanada qaba kansarka mindhicirka ay afka ka qaataan resveratrol, xiidanka bidix wuxuu nuugaa wax ka yar dhinaca midig, iyo lix metabolite, resveratrol-3-O-glucuronide iyo resveratrol-4'-O-glucuronide, ayaa la helaa. Resveratrol sulfate iyo glucuronide xeryahooda sida glucuronide, resveratrol-3-O-sulfate, iyo resveratrol-4′-O-sulfate.
