0102
Ku saabsan CAS 103-90-2 Acetaminophen
2024-05-10 09:37:28
| barta dhalaalaysa | 168-172 °C ( shidan) |
| Barta karkarinta | 273.17°C (qiyaasta qallafsan) |
| cufnaanta | 1,293 g/cm3 |
| cadaadiska uumiga | 0.008Pa at 25℃ |
| index refractive | 1.5810 (Qiyaas adag) |
| Fp | 11 °C |
| heerkulka kaydinta. | Jawi aan firfircoonayn, heerkulka qolka |
| milmay | ethanol: milma0.5M, cad, aan midab lahayn |
| pka | 9.86±0.13 (La saadaaliyay) |
| qaab | Crystals ama budada crystalline |
| midab | Caddaan |
Sharaxaad:
Acetaminophen, oo sidoo kale loo yaqaan paracetamol, waa iskudhis kiimiko oo leh caanaha molecular C8H9NO2. Waa dawo hoos timaada fasalka xanuunka xanuunka (xanuun-jabiyeyaasha) iyo antipyretics (xummad-yareeya). Dhisme ahaan, acetaminophen waa para-aminophenol derivative. Marka la eego sifooyinka jirka, acetaminophen waa budo crystalline cad oo si yar ugu milmay biyaha. Waxaa caadi ahaan lagu heli karaa qaabab kala duwan, oo ay ku jiraan kiniinno, kaabsal, iyo dareeraha ka joojinta, ee maamulka afka.
Isticmaalka:
Acetaminophen waxaa si weyn loo isticmaalaa si loo yareeyo xanuunka oo loo yareeyo qandhada. Waxaa lagu yaqaanaa waxtarkeeda si loo yareeyo xanuunka fudud ama dhexdhexaadka ah, sida madax-xanuun, murqo xanuun, iyo ilka-xanuun. Si ka duwan daawooyinka nonsteroid anti-inflammatory (NSAIDs), acetaminophen ma laha sifooyin muhiim ah oo ka hortagga bararka.
Habka saxda ah ee ficilka acetaminophen si buuxda looma fahmin, laakiin waxaa la rumeysan yahay inay ku lug leedahay joojinta enzym loo yaqaan cyclooxygenase (COX) ee habka dhexe ee neerfayaasha. Enzyme Tani waxay ku lug leedahay soo saarista prostaglandins, kaas oo door ka ciyaara dareenka xanuunka iyo xakamaynta heerkulka jidhka.
Acetaminophen waxaa loo tixgeliyaa ikhtiyaarka badbaadada leh ee xanuunka dhimista ee shakhsiyaadka aan u dulqaadan karin NSAIDs sababo la xiriira sida boogaha gastric ama cilladaha dhiigbaxa.
Cilmi-baadhis la xidhiidha:
Cilmi-baarista vitro In vitro, acetaminophen waxay sababtay xulashada 4.4-laab ee xakamaynta COX-2 (IC50 ee COX-1, 113.7 μM; IC50 ee COX-2, 25.8 μM). Ka dib maamulka afka, xannibaadda ex vivo ugu badnaan waxay ahayd 56% (COX-1) iyo 83% (COX-2). Heerarka plasma acetaminophen ayaa ka sarreeyay in vitro IC50 ee COX-2 ugu yaraan 5 saacadood ka dib qiyaasta. Qiimaha ex vivo IC50 ee acetaminophen (COX-1: 105.2 μM; COX-2: 26.3 μM) ayaa si wanaagsan u barbar dhigaya qiyamkeeda in vitro IC50. Si ka soo horjeeda fikradihii hore, acetaminophen waxay joojisaa COX-2 in ka badan 80%, darajo u dhiganta daawooyinka aan isteeroydhiska ee ka hortagga bararka (NSAIDs) iyo COX-2 xannibaadayaasha. Si kastaba ha ahaatee, maya>95% xannibaadda COX-1 ayaa lala xiriiriyay joojinta shaqada platelet [1]. Qiimaynta MTT waxay muujisay in acetaminophen (APAP) ee qiyaasta 50mM si weyn (p
Daraasadaha vivo: Maamulka acetaminophen (250 mg / kg, afka) ee jiirarka waxay keentay waxyeelo weyn (p