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Iibinta kulul CAS 52232-67-4 Teriparatide acetate qiimo wanaagsan oo ammaan ah gaarsiinta iibka kulul ee tayada sare leh iyo qanacsanaanta macaamiisha sare
qeexitaanka alaabta
| Magaca Guud | Teriparatide acetate |
| Lambarka CAS | 52232-67-4 |
| Miisaanka Molecular | 4177.77000 |
| Qaanuunka molecular | C181H291N55O51S2 |
| EINECS | 640-978-1 |
| Xasilooni | Hygroscopic |
| Muuqashada | budo |
| Xaaladda kaydinta | -20°C |
Fiidiyowga Alaabta
Isticmaalka Alaabta
Teriparatide waa agonist PHT, iyo qiimihiisu IC50 ee unugyada HEK293 waa 2 nM.Teripartite waxay dhexdhexaadin kartaa dheef-shiid kiimikaadka lafaha iyada oo la xakameynayo apoptosis osteoblast, kicinta unugyada xuubka lafaha iyo xoojinta kala duwanaanta osteoblast. Iyada oo la xakameynayo adenylate cyclase-cyclic adenosine monophosphate-protein kinase Waddada, PHT-ⅰ reseptors ee dusha sare ee osteoblasts, unugyada xuubka lafaha iyo unugyada dhuuxa lafta ayaa si isdaba-joog ah loo kiciyaa si kor loogu qaado kala duwanaanshaha osteoblasts oo ay u dheereeyaan noloshooda. Kicin fidinta khadadka unugyada osteoblastiga iyada oo loo marayo fosfat C-cytoplasmic calcium ion-protein kinase Jidka gudbinta calaamada Chemibook C; Iyadoo la xakameynayo dhaqdhaqaaqa firfircoonida ee PPARγ, kala soocida unugyada stromal ee xariiqyada adipocyte waa la dhimay tirada osteoblasts waa la kordhiyaa. Nidaaminta aan tooska ahayn ee koritaanka lafaha iyada oo la xakameynayo cytokines, tusaale ahaan, waxay keeni kartaa iGF-1 in lagu daro osteoblasts, sidaas darteed kor u qaadista lafaha; Dariiqa calaamadaynta Wnt ayaa nidaamisa habka samaynta lafaha, sidaas awgeed waxay kordhisaa samaynta lafaha.
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