Iibinta kulul CAS 16941-32-5 Glucagon oo leh daahir sare oo tayo sare leh qiimo wanaagsan iibka albaabka albaabka gaynta iyo qanacsanaanta macaamiisha sare

Shaqada ugu weyn ee glucagon waa inay kor u qaaddo kala-goynta glycogen oo ay soo saarto gulukoos si kor loogu qaado sonkorta dhiigga; Marka labaad, heerka adenosine monophosphate cyclic (cAMP) waxaa lagu kordhin karaa adenylate cyclase, sidaas darteed firfircoonida borotiinka kinase, firfircoonida lipase ee nudaha adipose iyo kor u qaadida lipolysis. Dhaqdhaqaaqa nidaamka cyclase myocardial adenylate, kor u dhaqdhaqaaqa fosforylase myocardial, kordhiso ururinta calcium ee myocardium, taas oo kor u qaadaya qandho myokardial, kordhinta wax soo saarka wadnaha iyo kor u cadaadiska dhiigga; Waxa kale oo ay kor u qaadi kartaa dheecaanka islet Chemicalbook, somatostatin, thyroxine iyo calcitonin; Kor u qaad sii deynta catecholamine ee dareemayaasha naxariista leh iyo unugyada chromaffin. Glucagon, insulin iyo somatostatin ayaa midba midka kale maamula si ay sonkorta dhiiga ugu ilaaliso heerka caadiga ah. Dheecaanka glucagon waxa uu u dhigmaa si ka duwan fiirsashada gulukooska dhiigga, isla markaana, dheecaanka glucagon waxa uu sidoo kale saameeyaa amino acids, maadada dufanka bilaashka ah ee plasma, α-adrenergic stimulator (norepinephrine), auxin sii daayo hormoonka xannibaadda iyo sidaas oo kale.

Glucagon waa hoormoon polypeptide-ka ah oo hal silsilad ah ka samaysan oo ay soo daayaan unugyada islet α2. Waa iska soo horjeeda physiological ee insulin. Saamaynta dheef-shiid kiimikaadka waxay la mid tahay kan adrenaline, waxayna leedahay shaqooyinka soo socda: 1. Shaqada kor u qaadista sonkorta dhiigga: waxay kicin kartaa fosforylase ee beerka, waxay kor u qaaddaa kala-goynta glycogen beerka iyo heterogenesis glycogen, waxayna kor u qaaddaa. sonkorta dhiiga. 2. Saamaynta inotropic ee togan: waxay kordhin kartaa maadada cAMP ee gudaha, kor u qaadida qanjidhada myocardial, kordhinta wax soo saarka wadnaha iyo shaqada istaroogga. Saameynteeda inotropic togan ayaa wali la samayn karaa ka dib markii glycoside wadnaha ku filan la mariyo, oo aan la xannibin propranolol. Inkasta oo ay kordhin karto garaaca wadnaha iyo dhiig-karka, ma keeni doonto arrhythmia. Habkani waa sida soo socota: ① Firfircoonida adenylate cyclase waxay ka dhigaysaa adenosine triphosphate inay isu beddesho adenosine monophosphate cyclic, taas oo kor u qaadaysa qanjidhada myocardial ee Buuga Kiimikada; ② Waxay kordhisaa burburka glycogen beerka oo kor u qaad heerka sonkorta dhiigga; ③ Kor u qaadista insulinta, wanaajiso isticmaalka gulukooska ee myocardium, iyo kor u qaadida glycolysis anaerobic ee myocardium, sidaas darteed hagaajinta dheef-shiid kiimikaadka myocardium. Marka lagu daro digitalis cardiac glycosides, waxay kordhin kartaa saameynta daaweynta. 3. Saamaynta kelyaha: balaadhisa xididdada dhiigga kelyaha, wanaaji socodka dhiigga kelyaha iyo kor u qaadida qashin-saarka sodium, potassium iyo calcium. 4. Saamaynta hab-dhiska dheefshiidka: Waxay sababi kartaa nasinta muruqa ee caloosha iyo duodenum, xiidmaha yar iyo xiidmaha, waxay joojisaa peristalsis caloosha, xiidmaha yar iyo xiidmaha, waxayna kordhisaa dheecaanka xameetida iyo dheecaanka xiidmaha. 5. Saamaynta nidaamka sirta ah: Ku faraxsan medulla adrenal oo kor u qaad sii deynta catecholamines. Waxa kale oo ay kor u qaadi kartaa dheecaanka insulin, hoormoonka tayroodhka, calcitonin iyo hormoonka koritaanka.