Nekuenderera mberi nekukura uye kukura kweindasitiri yemakemikari, kambani yedu yakawedzera ruzivo munzira refu yekutarisisa zvigadzirwa zvemishonga, kwete chete mukutonga kwemhando yechigadzirwa, asiwo mukutariswa kwevashandi vasati vatengesa uye mushure mekutengesa. , uye kuiswa kwezvigadzirwa zvezvigadzirwa. Izvo zvakanyanya zvinodikanwa zvekusimudzira nekusimudzira zvaita kuti kambani yedu ienderere mberi uye mberi, nguva yenzvimbo dzevatengi iri kuwedzera nekufara, uye chiyero chebhizinesi chiri kuwedzera gore negore, kusanganisira kusimudzira uye kutsvagisa kwezvinhu zvekuzora. Pamusoro pezvo, kambani yedu parizvino ine mabasa matsva arikuenderera mberi maererano nemishonga yemishonga. Isu tave kuvaka nzvimbo yekugadzira inodarika zviuru zvinomwe zvemamita kuti iite hunyanzvi mukugadzira resveratrol, tichiedza kuve mugadziri mukuru we resveratrol. mutengesi.
Saka chii chaizvo chinonzi resveratrol? Rega ndikupe sumo pfupi.
Resveratrol (3-4'-5-trihydroxystilbene) isiri-flavonoid polyphenol compound ine zita remakemikari inonzi 3,4',5-trihydroxy-1,2-diphenylethylene (3,4 ',5-Stilbenetriol), iyo molecular formula. is C14H12O3, uye molecular uremu i228.25. Kuonekwa kwe pure resveratrol kuchena kune yakareruka yeyero poda, isinganhuhwi, yakaoma kunyungudika mumvura, inonyungudika zviri nyore muorganic solvents senge ether, chloroform, methanol, ethanol, acetone, ethyl acetate, nezvimwewo, ine nzvimbo yekunyungudika ye253 ~ ~ 255°C. Sublimation tembiricha ndeye 261 ℃. Inogona kutaridzika yakatsvuka ine alkaline mhinduro senge ammonia mvura, uye inogona kuita neferric chloride-potassium ferricyanide kugadzira ruvara. Ichi chivakwa chinogona kushandiswa kuona resveratrol.
Natural resveratrol ine zvimiro zviviri, cis uye trans. Iyo inonyanya kuvepo mune trans conformation mune zvakasikwa. Izvo zvimiro zviviri zvinogona kusanganiswa neglucose zvakateerana kuita cis uye trans resveratrol glycosides. Iyo cis- uye trans-resveratrol glycosides inogona kuburitsa resveratrol pasi pechiito che glycosidases muura. Pasi pe UV mwenje irradiation, trans-resveratrol inogona kushandurwa kuita cis-isomer.
Resveratrol inogadzira fluorescence pasi pe366nm ultraviolet mwenje. Jeandet et al. yakasarudza iyo UV spectral maitiro e resveratrol uye ayo infrared absorption peaks pa 2800 ~ 3500cm (OH bond) uye 965cm (trans form yekaviri bond). Ongororo dzakaratidza kuti trans-resveratrol yakagadzikana kunyangwe ikasiiwa kwemwedzi yakati wandei, kunze kwekunge yakakwira pH buffers, chero yakanyatsoparadzaniswa nechiedza.
Resveratrol ine yakaderera bioavailability mumuviri, nezvidzidzo zvinoratidza kuti bioavailability ye resveratrol metabolites mudumbu diki uye chiropa ingangoita 1%. Resveratrol inokurumidza kugadzirwa mumhuka uye inosvika pakukosha kwayo muplasma mukati me5 maminetsi. Zvidzidzo zvemetabolism mumhuka zvakaona kuti resveratrol inonyanya kushandiswa mumhuka dzinoyamwisa dzakadai semakonzo, nguruve, imbwa, nezvimwewo nenzira ye resveratrol sulfate esterification uye glucuronidation zvigadzirwa. Zvidzidzo zvakasimbisa kuti resveratrol inogovaniswa mumhando dzakasungwa mumhando dzakasiyana dzemhuka dzinoyamwisa, uye resveratrol inonyanya kunyudzwa uye kugoverwa munhengo dzine hupfumi hweropa, senge chiropa, itsvo, moyo uye uropi. Kuburikidza netsvagiridzo yemetabolism ye resveratrol mumuviri wemunhu, zvakaonekwa kuti kuwanda kwe resveratrol muplasma yevanhuwo zvavo kwakaratidza "double peak phenomenon" mushure mekutonga nemuromo, asi pakanga pasina chiitiko chakadaro mushure mekutonga kwe iv (jekiseni remutsinga) ; kusanganiswa kwe resveratrol mu plasma mushure mekutonga kwemuromo Zvinhu zvikuru zvedoro metabolism ndeye glucuronidation uye sulfate esterification. Mushure mokunge varwere vane kenza yakaoma vatora resveratrol nemuromo, koloni yekuruboshwe inotora zvishoma kudarika rutivi rworudyi, uye metabolites matanhatu, resveratrol-3-O-glucuronide uye resveratrol-4'-O-glucuronide, inowanikwa. Resveratrol sulfate uye glucuronide mishonga yakadai seglucuronide, resveratrol-3-O-sulfate, uye resveratrol-4'-O-sulfate.
