0102
Nezve CAS 103-90-2 Acetaminophen
2024-05-10 09:37:28
| Melting point | 168-172 °C(lit.) |
| Boiling point | 273.17°C (yakaomarara fungidziro) |
| density | 1,293 g/cm3 |
| mhute pressure | 0.008Pa pa25 ℃ |
| refractive index | 1.5810 (yakaomarara fungidziro) |
| Fp | 11 °C |
| kuchengetedza temp. | Inert mamiriro, Room Temperature |
| solubility | ethanol: soluble0.5M, yakajeka, isina ruvara |
| pka | 9.86±0.13(Zvakafanotaurwa) |
| form | Makristasi kana Crystalline Powder |
| color | Chena |
Tsanangudzo:
Acetaminophen, inozivikanwawo separacetamol, ikemikari inosanganiswa neiyo molecular formula C8H9NO2. Ndiyo mishonga inowira pasi pekirasi yeanalgesics (marwadzo ekudzivirira) uye antipyretics (fever reducers). Zvimiro, acetaminophen ndeye para-aminophenol derivative. Panyaya yezvimiro zvemuviri, acetaminophen iwhite crystalline poda inonyungudika zvishoma mumvura. Inowanzo kuwanikwa mumhando dzakasiyana-siyana, kusanganisira mahwendefa, capsules, uye kumiswa kwemvura, yekutonga nemuromo.
Zvishandiso:
Acetaminophen inoshandiswa zvakanyanya kuderedza marwadzo uye kuderedza kupisa. Inozivikanwa nekubudirira kwayo mukubvisa marwadzo ari pakati nepakati, akadai sekutemwa nemusoro, kurwadza kwetsandanyama, uye kutemwa nemazino. Kusiyana ne-nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen haina zvakakosha anti-inflammatory properties.
Iyo chaiyo nzira yekuita kweacetaminophen haina kunyatsonzwisiswa, asi inotendwa kuti inosanganisira kuvharirwa kwe enzyme inonzi cyclooxygenase (COX) mukati mepakati tsinga system. Iyi enzyme inobatanidzwa mukugadzirwa kweprostaglandin, iyo inobata basa mukunzwisisa marwadzo uye kugadzirisa kupisa kwemuviri.
Acetaminophen inoonekwa seyakachengeteka sarudzo yekuzorodza marwadzo kune vanhu vasingakwanisi kushivirira NSAID nekuda kwezvinhu zvakaita semaronda emudumbu kana kusagadzikana kwekubuda ropa.
Tsvakurudzo inoenderana:
In vitro zvidzidzo In vitro, acetaminophen yakakonzera 4.4-fold selectivity ye COX-2 inhibition (IC50 ye COX-1, 113.7 μM; IC50 ye COX-2, 25.8 μM). Mushure mekutonga nemuromo, yakanyanya ex vivo inhibition yaive 56% (COX-1) uye 83% (COX-2). Acetaminophen plasma concentrations yakaramba iri pamusoro peiyo in vitro IC50 yeCOX-2 kweinenge maawa mashanu mushure mekuita dosing. Iyo ex vivo IC50 tsika dzeacetaminophen (COX-1: 105.2 μM; COX-2: 26.3 μM) inoenzanisa zvakanaka neiyo in vitro IC50 kukosha. Kusiyana nemafungiro ekare, acetaminophen inhibits COX-2 nevanopfuura 80%, dhigirii inofananidzwa nemishonga inopesana nekuputika (NSAIDs) uye yakasarudzwa COX-2 inhibitors. Zvisinei, kwete> 95% COX-1 blockade yakabatanidzwa nekudzivisa kweplatelet function [1]. MTT assay yakaratidza kuti acetaminophen (APAP) pachiyero che50mM zvakanyanya (p
In vivo zvidzidzo: Kutungamirirwa kweacetaminophen (250 mg/kg, nemuromo) kumakonzo kwakaguma nekukosha (p