Kupisa kutengesa CAS 16941-32-5 Glucagon ine kuchena kwepamusoro mhando yakanaka mutengo unopisa wekutengesa dhoo remusuwo kuunza uye yakakwirira kugutsikana kwevatengi.

Basa guru reglucagon nderekusimudzira glycogen kuora uye kubudisa glucose kukwidza shuga yeropa; Chechipiri, mwero wecyclic adenosine monophosphate (cAMP) unogona kuwedzerwa neadenylate cyclase, nokudaro activate protein kinase, activating lipase muadipose tissue uye kusimudzira lipolysis. Activate myocardial adenylate cyclase system, kusimudzira basa remyocardial phosphorylase, kuwedzera kuunganidzwa kwecalcium mumyocardium, nekudaro kunowedzera myocardial contractility, kuwedzera kuburitsa kwemoyo uye kukwidza BP; Inogonawo kukurudzira secretion ye islet Chemicalbook, somatostatin, thyroxine uye calcitonin; Kurudzira kuburitswa kwekatecholamine kubva kutsitsi dzetsinga uye chromaffin masero. Glucagon, insulin uye somatostatin inorongana kuchengetedza shuga yeropa iri mumhando yakajairika. Kudzivirirwa kweglucagon kunopesana nehupamhi hweshuga yeropa, uye panguva imwecheteyo, secretion yeglucagon inobatwawo neamino acids, plasma isina mafuta ane acid content, α -adrenergic receptor stimulator (norepinephrine), auxin release inhibitory hormone uye. zvichingodaro.

Glucagon ndeye-single-chain polypeptide hormone yakagadzirwa uye yakavanzwa neislet α2 masero. Iyo physiological antagonist ye insulin. Mhedzisiro yemetabolism yakafanana neyeye adrenaline, uye ine mabasa anotevera: 1. Basa rekusimudza shuga yeropa: inogona kushandura phosphorylase muchiropa, kukurudzira kuora kwechiropa glycogen uye heterogenesis yeglycogen, uye kusimudza. shuga yeropa. 2. Positive inotropic effect: inogona kuwedzera intracellular cAMP content, kuwedzera myocardial contractility, kuwedzera kubuda kwemwoyo uye basa rekurohwa. Yayo yakanaka inotropic effect inogona kushandiswa mushure mokunge cardiac glycoside yakakwana inoshandiswa, uye haina kuvharwa nepropranolol. Kunyangwe ichigona kuwedzera kurova kwemoyo uye hypertension, haizokonzerese arrhythmia. Iyo mashini ndeiyi inotevera: ① Kuita kweadenylate cyclase kunoita kuti adenosine triphosphate ichinje kuita cyclic adenosine monophosphate, iyo inosimudzira iyo myocardial contractility ye Chemicalbook; ② Kurudzira kuora kwechiropa glycogen uye kusimudza chiyero cheshuga yeropa; ③ Kurudzira kuburitswa kwe insulin, kunatsiridza kushandiswa kweglucose nemyocardium, uye kukurudzira anaerobic glycolysis yemyocardium, nokudaro kuvandudza simba remetabolism yemyocardium. Yakasanganiswa ne digitalis cardiac glycosides, inogona kuwedzera kurapa maitiro. 3. Mhedzisiro paitsvo: dilate renal tsinga dzeropa, kuvandudza renal kuyerera kweropa uye kukurudzira kubuda kwe sodium, potassium uye calcium. . 5. Mhedzisiro pane secretory system: Excite adrenal medulla uye kukurudzira kusunungurwa kwekatecholamines. Inogonawo kukurudzira kugadzirwa kwe insulin, thyroid hormone, calcitonin uye kukura kwehomoni.