Hamwe niterambere rihoraho hamwe nubukure bwinganda zikora imiti, isosiyete yacu yarushijeho kuba inararibonye mumuhanda muremure wo kwibanda kubikoresho fatizo bya farumasi, ntabwo ari ukugenzura ubuziranenge bwibicuruzwa gusa, ahubwo no kugenzura abakozi mbere na nyuma yo kugurisha , no kumenyekanisha ibikoresho byibicuruzwa. Ibisabwa bikomeye byo kuzamura no kuzamura byatumye uruganda rwacu rugenda rutera imbere, umwanya w’abakiriya uragenda waguka, kandi n’ubucuruzi nabwo buragenda bwiyongera uko umwaka utashye, harimo guteza imbere n’ubushakashatsi ku bikoresho fatizo byo kwisiga. Mubyongeyeho, isosiyete yacu kuri ubu ifite imirimo mishya iri gukorwa mubijyanye nibikoresho bya farumasi. Ubu turimo kubaka ubuso bungana na metero kare zirenga 7000 kugirango tuzobereye mu gukora resveratrol, duharanira kuba nyirabayazana wa resveratrol. utanga isoko.
None se resveratrol ni iki? Reka nguhe intangiriro ngufi.
Resveratrol (3-4'-5-trihydroxystilbene) ni uruganda rutari flavonoide polifenol rufite izina ryimiti ni 3,4 ', 5-trihydroxy-1,2-diphenylethylene (3,4', 5-Stilbenetriol) ni C14H12O3, naho uburemere bwa molekile ni 228.25. Kugaragara kwa resveratrol yera ni ifu yumuhondo yoroheje, impumuro nziza, bigoye gushonga mumazi, byoroshye gushonga mumashanyarazi nka ether, chloroform, methanol, Ethanol, acetone, etil acetate, nibindi, hamwe na 253 ~ 255 ° C. Ubushyuhe bwo hejuru ni 261 ℃. Irashobora kugaragara itukura hamwe nibisubizo bya alkaline nkamazi ya amoniya, kandi irashobora kwitwara hamwe na ferric chloride-potassium ferricyanide kugirango ikure ibara. Uyu mutungo urashobora gukoreshwa kugirango umenye resveratrol.
Resveratrol isanzwe ifite ibyiciro bibiri, cis na trans. Bibaho cyane cyane muburyo bwo guhindura ibintu muri kamere. Inzego zombi zishobora guhuzwa na glucose muburyo bwo gukora cis na trans resveratrol glycoside. Cis- na trans-resveratrol glycoside irashobora kurekura resveratrol ikorwa na glycosidase mu mara. Munsi ya UV yumucyo, trans-resveratrol irashobora guhinduka muri cis-isomer.
Resveratrol itanga fluorescence munsi ya 366nm ultraviolet. Jeandet n'abandi. yagennye ibiranga UV biranga resveratrol hamwe na infragre yo kwinjirira hejuru ya 2800 ~ 3500cm (OH bond) na 965cm (trans form yuburyo bubiri). Ubushakashatsi bwerekanye ko trans-resveratrol itajegajega niyo isigara amezi menshi, usibye muri bufferi ndende ya pH, mugihe cyose itandukanijwe numucyo.
Resveratrol ifite bioavailable nkeya mumubiri, hamwe nubushakashatsi bwerekana ko bioavailable ya resveratrol metabolite mumara mato numwijima bigera kuri 1%. Resveratrol ihindagurika vuba mu nyamaswa kandi igera ku gipimo cyayo cya plasma mu minota 5. Ubushakashatsi bwa Metabolism mu nyamaswa bwerekanye ko resveratrol ikoreshwa cyane mu nyamaswa z’inyamabere nk'imbeba, ingurube, imbwa, n'ibindi mu buryo bwa resveratrol sulfate esterification n'ibicuruzwa bya glucuronidation. Ubushakashatsi bwemeje ko resveratrol ikwirakwizwa mu buryo butandukanye mu nyama zitandukanye z’inyamabere, kandi resveratrol irinjira cyane kandi igakwirakwizwa mu ngingo zifite amaraso menshi, nk'umwijima, impyiko, umutima n'ubwonko. Binyuze mu bushakashatsi bwakozwe kuri metabolism ya resveratrol mu mubiri w’umuntu, byagaragaye ko kwibumbira hamwe kwa resveratrol muri plasma yabantu basanzwe byerekanaga "ibintu bibiri byikurikiranya" nyuma yubuyobozi bwo mu kanwa, ariko ntakintu nakimwe cyabayeho nyuma yubuyobozi bwa iv (inshinge zinjirira) ; kwibumbira hamwe kwa resveratrol muri plasma nyuma yubuyobozi bwo munwa Ibicuruzwa nyamukuru bya metabolisme ya alcool ni glucuronidation na sulfate esterification. Nyuma yuko abarwayi ba kanseri yibara bafata resveratrol kumunwa, ururenda rwibumoso rwinjiza munsi yuruhande rwiburyo, hanyuma haboneka metabolite esheshatu, resveratrol-3-O-glucuronide na resveratrol-4′-O-glucuronide. Resveratrol sulfate na glucuronide ivanze nka glucuronide, resveratrol-3-O-sulfate, na resveratrol-4′-O-sulfate.
