Hafi ya CAS 103-90-2 Acetaminofeni
2024-05-10 09:37:28
| Ingingo yo gushonga | 168-172 ° C (lit.) |
| Ingingo yo guteka | 273.17 ° C (igereranya) |
| ubucucike | 1,293 g / cm3 |
| umuvuduko w'umwuka | 0.008Pa kuri 25 ℃ |
| indangagaciro | 1.5810 (igereranya) |
| Fp | 11 ° C. |
| ububiko bwa temp. | Ikirere cyimbere, Ubushyuhe bwicyumba |
| gukemura | Ethanol: gushonga0.5M, bisobanutse, bitagira ibara |
| pka | 9.86 ± 0.13 (Byahanuwe) |
| ifishi | Ifu ya Crystal cyangwa Ifu ya Crystalline |
| ibara | Cyera |
Ibisobanuro:
Acetaminofen, izwi kandi nka parasetamol, ni imiti ivangwa na molekile ya C8H9NO2. Numuti ugwa munsi yicyiciro cya analgesics (kugabanya ububabare) na antipyretics (kugabanya umuriro). Mu buryo bwubaka, acetaminofeni ikomoka kuri para-aminofenol. Kubijyanye nimiterere yumubiri, acetaminofeni ni ifu yera ya kristaline yera idashonga cyane mumazi. Iraboneka mubisanzwe muburyo butandukanye, harimo ibinini, capsules, hamwe no guhagarika amazi, kubuyobozi bwo munwa.
Gukoresha ：
Acetaminofeni ikoreshwa cyane mu kugabanya ububabare no kugabanya umuriro. Azwiho akamaro ko kugabanya ububabare bworoheje kandi butagereranywa, nko kubabara umutwe, kubabara imitsi, no kubabaza amenyo. Bitandukanye n’imiti idakira ya anti-inflammatory (NSAIDs), acetaminofeni ntabwo ifite imiti igabanya ubukana.
Uburyo nyabwo bwibikorwa bya acetaminofeni ntabwo bwumvikana neza, ariko bikekwa ko harimo no kubuza umusemburo witwa cyclooxygenase (COX) muri sisitemu yo hagati. Iyi misemburo igira uruhare mu gukora prostaglandine, igira uruhare mu myumvire yububabare no kugenzura ubushyuhe bwumubiri.
Acetaminofeni ifatwa nk'uburyo bwizewe bwo kugabanya ububabare ku bantu badashobora kwihanganira NSAIDs bitewe n'impamvu nk'ibisebe byo mu gifu cyangwa indwara yo kuva amaraso.
Ubushakashatsi bujyanye ：
Mu bushakashatsi bwa vitro Muri vitro, acetaminofeni yateje inshuro 4.4 guhitamo COX-2 kubuza (IC50 kuri COX-1, 113.7 μM; IC50 kuri COX-2, 25.8 μM). Nyuma yubuyobozi bwo mu kanwa, ntarengwa ex vivo yabujijwe yari 56% (COX-1) na 83% (COX-2). Imyunyungugu ya Acetaminofen yagumye hejuru ya vitro IC50 ya COX-2 byibuze amasaha 5 nyuma yo kunywa. Ex vivo IC50 indangagaciro za acetaminofeni (COX-1: 105.2 μM; COX-2: 26.3 μM) igereranya neza nindangagaciro za vitro IC50. Bitandukanye n’ibitekerezo byabanjirije iki, acetaminofeni ibuza COX-2 hejuru ya 80%, impamyabumenyi igereranywa n’imiti igabanya ubukana (NSAIDs) hamwe na COX-2 ihitamo. Ariko, nta> 95% COX-1 kuzitira byajyanye no kubuza imikorere ya platine [1]. Ubushakashatsi bwa MTT bwerekanye ko acetaminofeni (APAP) ku kigero cya 50mM ku buryo bugaragara (p
Mu bushakashatsi bwa vivo: Ubuyobozi bwa acetaminofeni (250 mg / kg, mu kanwa) ku mbeba byaviriyemo kwangirika kwumwijima (p