Uruganda rufite isuku ryinshi 98% Peptide Ifu ya Liraglutide CAS 204656-20-2 Ifu ya peptide muri Viali igiciro gito cyiza peptide Amavuta yo kwisiga

Liraglutide (NN2211) ni glucagon ikora cyane nka peptide-1 reseptor agonist. Igurishwa ku izina rya Victoza, ni imiti yatewe inshinge yakozwe na Novo Nordisk yo kuvura diyabete yo mu bwoko bwa 2. Muri 2015, Novo Nordisk yatangiye kuyicuruza muri Amerika ku izina rya liraglutide mu rwego rwo kuvura umubyibuho ukabije ku bantu bakuru bafite byibura indwara imwe ya comorbid.

Gukoresha Ubuvuzi

Liraglutide ni inshuro imwe buri munsi ikomoka ku nshuro ya incretine ya muntu (hormone metabolike) glucagon imeze nka peptide-1 (GLP-1), kugirango ivure diyabete yo mu bwoko bwa 2 cyangwa umubyibuho ukabije.

Ubwoko bwa 2 Diyabete

Liraglutide itunganya neza glucose yamaraso. Gutinda gusiba gastric, no guhagarika ururenda rwa glucagon.

Mubisanzwe mubyiciro bitandukanye hamwe nabandi GLP-1 reseptor agonist, liraglutide ifite ibyiza kurenza imiti gakondo ya diyabete yo mu bwoko bwa 2:

Ifite ubushobozi bwo guhagarika apoptose no gutera imbaraga kuvugurura ingirabuzimafatizo (bigaragara mu bushakashatsi bw’inyamaswa).

Igabanya ubushake bwo kurya no kubuza kwiyongera k'umubiri, nkuko bigaragara mu bushakashatsi bwakozwe ku mutwe na glimepiride.

Igabanya urugero rwa triglyceride.

Umubyibuho ukabije

Liraglutide yemerewe nk'inshinge zifata indyo yagabanijwe-ya calorie kandi yongera imyitozo ngororamubiri yo gucunga ibiro bidakira ku barwayi bakuze. Ibipimo byagenwe ni ibipimo byambere byumubiri (BMI) bya 30 kg / m2 cyangwa birenga (umubyibuho ukabije), cyangwa 27 kg / m2 cyangwa birenga (birenze urugero), imbere yiburiburi byibuze kimwe kijyanye n'uburemere (urugero: hypertension, ubwoko bwa 2 diabete mellitus, cyangwa dyslipidemia). Mu mpera z'umwaka wa 2014, amakuru yavuzwe mu bushakashatsi bwa SCALE ™ Umubyibuho ukabije na Prediabete, ni ikigereranyo cyateganijwe, gihumye-impumyi, kigenzurwa na platbo, ibihugu byinshi ku bantu badafite diyabete bafite umubyibuho ukabije ndetse n'abantu badafite diyabete bafite ibiro byinshi hamwe n'ingaruka. Muri iki cyiciro cya 3a, hari abantu 3,731 bitabiriye kwivuza hamwe na liraglutide 3 mg cyangwa umwanya wabo, haba hamwe nimirire no gukora siporo. Abarangije igeragezwa ryibyumweru 56 bageze ku kigereranyo cyo kugabanya ibiro 9.2%, ugereranije no kugabanuka kwa 3.5% mumatsinda yabobo.