Kugurisha bishyushye CAS 16941-32-5 Glucagon hamwe nubuziranenge buhanitse ubuziranenge bwiza igiciro cyiza kugurisha kugurisha urugi kugeza kumuryango no guhaza abakiriya benshi

Igikorwa nyamukuru cya glucagon nuguteza imbere glycogene no kubora glucose kugirango isukari yamaraso; Icya kabiri, urwego rwa cyclic adenosine monophosphate (cAMP) rushobora kwiyongera na adenylate cyclase, bityo igakora protein kinase, igakora lipase mumyanya ya adipose kandi igatera lipolysis. Koresha sisitemu ya myocardial adenylate cyclase, guteza imbere ibikorwa bya fosifori ya myocardial, kongera ikwirakwizwa rya calcium muri myocardium, bityo bikongerera myocardial kwandura, kongera umutima ndetse no kuzamura umuvuduko wamaraso; Irashobora kandi guteza imbere gusohora kwa Islet Chemical Book, somatostatin, thyroxine na calcitonine; Teza imbere irekurwa rya catecholamine muri selile yimpuhwe hamwe na chromaffin. Glucagon, insuline na somatostatine bigenga buri kimwe kugirango isukari yamaraso igabanuke mubisanzwe. Isohora rya glucagon rihwanye cyane n’amaraso ya glucose, kandi muri icyo gihe, isohoka rya glucagon naryo ryibasirwa na aside amine, plasma irimo aside irike, α -adrenergic reseptor stimulator (norepinephrine), imisemburo ya auxin irekura kandi n'ibindi.

Glucagon ni imisemburo imwe ya polypeptide ya hormone ikomatanya kandi ikarekurwa na selile α2 selile. Numubiri urwanya insuline. Ingaruka kuri metabolisme isa n'iya adrenaline, kandi ifite imirimo ikurikira: 1. Igikorwa cyo kuzamura isukari mu maraso: irashobora gukora fosifori mu mwijima, igatera kwangirika kw'umwijima glycogene na heterogenezi ya glycogene, kandi ikazamura isukari mu maraso. 2. Ingaruka nziza ya inotropique: irashobora kongera ibintu bya cAMP idasanzwe, kongera imbaraga za myocardial, kongera umusaruro wumutima hamwe nakazi ka stroke. Ingaruka nziza ya inotropique irashobora gukoreshwa nyuma yumutima uhagije wa glycoside yumutima, kandi ntabwo ihagarikwa na propranolol. Nubwo ishobora kongera umuvuduko wumutima hamwe na hypertension, ntabwo bizatera kurwara. Ubu buryo ni ubu bukurikira: ① Gukora cyclase ya adenylate bituma adenosine triphosphate ihinduka muri cyclic adenosine monophosphate, ibyo bikaba byongera ubukana bwa myocardial ya Chemical Book; Guteza imbere kubora umwijima glycogene no kuzamura isukari mu maraso; Guteza imbere kurekura insuline, kunoza imikoreshereze ya glucose na myocardium, no guteza imbere anaerobic glycolysis ya myocardium, bityo bikazamura imbaraga za metabolisme ya myocardium. Ufatanije na digitalis cardiac glycoside, irashobora kongera ingaruka zo gukiza. 3. Ingaruka ku mpyiko: kwagura imiyoboro yamaraso yimpyiko, kunoza amaraso yimpyiko no guteza imbere sodium, potasiyumu na calcium. 4 5. Ingaruka kuri sisitemu yubunyamabanga: Shimisha medrenla adrenal kandi utezimbere irekurwa rya catecholamine. Irashobora kandi guteza imbere gusohora insuline, imisemburo ya tiroyide, calcitonine na hormone yo gukura.