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Choyambirira cha semaglutide chidapangidwa ndi Novo Nordisk ndipo chimasonyezedwa kwa akuluakulu omwe ali ndi matenda a shuga a 2. Dzina lamalonda lamankhwala ojambulira ndi Ozempic®, omwe amatha kugwiritsidwa ntchito kamodzi pa sabata. Linavomerezedwa kuti lizigulitsidwa ndi US Food and Drug Administration (FDA) pa December 5, 2017, ndi European Medicines Agency (EMA) pa February 8, 2018. Linavomerezedwa kuti lizigulitsidwa ndi Japan Pharmaceuticals and Medical Devices Agency ( PMDA) pa Marichi 23, 2018. Ntchito yotsatsa idatumizidwa ku China Medical Products Administration (NMPA) pa Epulo 4, 2020, ndipo pano ikuwunikidwa ndi kuvomerezedwa. Dzina lachidziwitso chamankhwala a piritsi yapakamwa, Rybelsus®, lidavomerezedwa ndi FDA pa Seputembara 20, 2019, European EMA mu Marichi 2020, ndi Japan PMDA mu June 2020. Ndi mankhwala oyamba akumwa a GLP-1 padziko lonse lapansi. Semaglutide (jekeseni wa 0.5 mg kapena 1 mg) angagwiritsidwe ntchito pochiza matenda a shuga a 2 mwa akuluakulu. Mankhwalawa ndi glucagon-ngati peptide (GLP-1) receptor agonist, omwe amathandizira katulutsidwe ka insulini komanso amachepetsa katulutsidwe ka glucagon. Theka la moyo womanga magazi albumin ndi 1 sabata, choncho ayenera kuperekedwa kamodzi pa sabata ndi prefilled cholembera. Imathandizira zakudya komanso masewera olimbitsa thupi kuti ziwongolere shuga m'magazi mwa akulu omwe ali ndi matenda amtundu wa 2.