Kugulitsa kwachindunji kwa fakitale Pregabalin CAS 148553-50-8 yokhala ndi zabwino kwambiri komanso mtengo wotsika kwambiri pazotetezedwa komanso zotumizira mwachangu zapakatikati

Pregabalin ndi mankhwala omwe amagwera pansi pa gulu la anticonvulsant. Pregabalin ndi yochokera ku gamma-aminobutyric acid (GABA), neurotransmitter mu dongosolo lapakati lamanjenje. Mwamapangidwe, imagwirizana ndi GABA yoletsa neurotransmitter, koma momwe amagwirira ntchito ndi yosiyana. Pankhani ya zinthu zakuthupi, pregabalin ndi cholimba cha crystalline choyera. Kusungunuka kwake kumaphatikizapo kukhala osasungunuka m'madzi komanso kusungunuka momasuka mu zosungunulira za polar organic. Pregabalin imapezeka m'njira zapakamwa, monga makapisozi kapena mapiritsi, kuti azigwiritsidwa ntchito ngati mankhwala.

Pregabalin amagwiritsidwa ntchito pochiza matenda osiyanasiyana, kuphatikizapo ululu wa neuropathic, fibromyalgia, ndi mitundu ina ya khunyu. Imakhala ndi zotsatira zake zochiritsira pomangirira ku alpha-2-delta subunit ya voltage-gated calcium channels m'katikati mwa mitsempha ya mitsempha. Kumangiriza kumeneku kumathandizira kuchuluka kwa ma ayoni a calcium, kumachepetsa kutulutsa kwa ma neurotransmitters, ndipo potero kumachepetsa chisangalalo cha ma cell a mitsempha.