Ndi chitukuko chosalekeza ndi kukhwima kwa makampani opanga mankhwala, kampani yathu yakhala ikuchulukirachulukira mumsewu wautali woganizira kwambiri zopangira mankhwala, osati poyang'anira khalidwe la mankhwala, komanso kuyang'anira antchito asanayambe kapena atatha kugulitsa. , ndi kuyambitsa zida zopangira mankhwala. Zomwe zimafunikira pakukweza ndi kukweza zidapangitsa kuti kampani yathu ipite patsogolo, kuchuluka kwamakasitomala kukuchulukirachulukira, komanso kuchuluka kwa bizinesi kukukulirakulira chaka ndi chaka, kuphatikiza kupanga ndi kafukufuku wazinthu zodzikongoletsera. Kuphatikiza apo, kampani yathu pakadali pano ili ndi ntchito zatsopano zomwe zikuchitika pankhani yazamankhwala. Tsopano tikumanga malo opangira malo opitilira 7,000 masikweya mita kuti tigwire ntchito yopanga resveratrol, kuyesetsa kukhala wopanga wamkulu wa resveratrol. wogulitsa.
Ndiye kodi resveratrol ndi chiyani kwenikweni? Ndiroleni ndikufotokozereni mwachidule.
Resveratrol (3-4'-5-trihydroxystilbene) ndi non-flavonoid polyphenol pawiri dzina lake mankhwala ndi 3,4',5-trihydroxy-1,2-diphenylethylene (3,4 ',5-Stilbenetriol), molecular formula. ndi C14H12O3, ndipo kulemera kwa maselo ndi 228.25. Maonekedwe a resveratrol koyera ndi woyera mpaka kuwala chikasu ufa, fungo, zovuta kusungunuka m'madzi, mosavuta sungunuka mu zosungunulira organic monga etha, chloroform, methanol, Mowa, acetone, ethyl acetate, ndi zina zotero, ndi malo osungunuka 253 ~ ~ ~ ~ 255 ° C. Kutentha kwa sublimation ndi 261 ℃. Itha kuwoneka yofiira ndi njira za alkaline monga madzi ammonia, ndipo imatha kuchitapo kanthu ndi ferric chloride-potaziyamu ferricyanide kuti ipangike mtundu. Katunduyu angagwiritsidwe ntchito kuzindikira resveratrol.
Natural resveratrol ili ndi magawo awiri, cis ndi trans. Zimapezeka makamaka mu trans conformation mu chilengedwe. Mapangidwe awiriwa amatha kuphatikizidwa ndi shuga motsatana kuti apange cis ndi trans resveratrol glycosides. Ma cis- ndi trans-resveratrol glycosides amatha kutulutsa resveratrol pansi pa zochita za glycosidases m'matumbo. Pansi pa kuwala kwa UV, trans-resveratrol imatha kusinthidwa kukhala cis-isomer.
Resveratrol imapanga fluorescence pansi pa 366nm ultraviolet kuwala. Jeandet et al. adatsimikiza mawonekedwe a UV a resveratrol ndi mayamwidwe ake a infrared pa 2800 ~ 3500cm (OH bond) ndi 965cm (transform of double bond). Mayesero awonetsa kuti trans-resveratrol ndi yokhazikika ngakhale itasiyidwa kwa miyezi ingapo, kupatula pa pH buffers, bola ngati ili kutali kwambiri ndi kuwala.
Resveratrol imakhala ndi bioavailability yochepa m'thupi, ndi kafukufuku wosonyeza kuti bioavailability wa resveratrol metabolites m'matumbo aang'ono ndi chiwindi ndi pafupifupi 1%. Resveratrol imapangidwa mwachangu mu nyama ndipo imafika pachimake mu plasma mkati mwa mphindi 5. Maphunziro a metabolism mu nyama apeza kuti resveratrol imapangidwa makamaka ndi nyama zoyamwitsa monga makoswe, nkhumba, agalu, ndi zina zotero mu mawonekedwe a resveratrol sulfate esterification ndi glucuronidation mankhwala. Kafukufuku watsimikizira kuti resveratrol imagawidwa m'magulu osiyanasiyana a nyama zoyamwitsa, ndipo resveratrol imatengedwa kwambiri ndikugawidwa mu ziwalo zokhala ndi magazi ambiri, monga chiwindi, impso, mtima ndi ubongo. Kupyolera mu kafukufuku wokhudza kagayidwe ka resveratrol m'thupi la munthu, zidapezeka kuti kuchuluka kwa resveratrol m'madzi a m'magazi a anthu wamba kumawonetsa "chochitika chambiri" pambuyo poyang'anira pakamwa, koma panalibe chodabwitsa chotere pambuyo pa jekeseni wa iv (jekeseni wa mtsempha). ; Kuchuluka kwa resveratrol mu plasma pambuyo poyamwitsa pakamwa Zinthu zazikulu za kagayidwe ka mowa ndi glucuronidation ndi sulfate esterification. Odwala omwe ali ndi khansa ya colorectal atenga resveratrol pakamwa, m'matumbo akumanzere amatenga zochepa kuposa kumanja, ndipo ma metabolites asanu ndi limodzi, resveratrol-3-O-glucuronide ndi resveratrol-4'-O-glucuronide, amapezeka. Resveratrol sulfate ndi glucuronide mankhwala monga glucuronide, resveratrol-3-O-sulfate, ndi resveratrol-4'-O-sulfate.
