0102
Za CAS 103-90-2 Acetaminophen
2024-05-10 09:37:28
| Malo osungunuka | 168-172 °C (kuyatsa) |
| Malo otentha | 273.17 ° C (kuyerekeza molakwika) |
| kachulukidwe | 1,293 g/cm3 |
| kuthamanga kwa nthunzi | 0.008Pa pa 25 ℃ |
| refractive index | 1.5810 (kuyerekeza molakwika) |
| Fp | 11 °C |
| kutentha kutentha. | Mkhalidwe Wosakhazikika, Kutentha kwa Zipinda |
| kusungunuka | ethanol: soluble0.5M, zomveka, zopanda mtundu |
| pka | 9.86±0.13 (Zonenedweratu) |
| mawonekedwe | Makristalo kapena ufa wa crystalline |
| mtundu | Choyera |
Kufotokozera:
Acetaminophen, yomwe imadziwikanso kuti paracetamol, ndi mankhwala omwe ali ndi formula ya C8H9NO2. Ndi mankhwala omwe amagwera pansi pa gulu la analgesics (ochotsa ululu) ndi antipyretics (ochepetsa malungo). Mwamapangidwe, acetaminophen ndi yochokera ku para-aminophenol. Pankhani yakuthupi, acetaminophen ndi ufa woyera wa crystalline womwe umasungunuka pang'ono m'madzi. Nthawi zambiri amapezeka m'mapangidwe osiyanasiyana, kuphatikiza mapiritsi, makapisozi, ndi kuyimitsidwa kwamadzimadzi, kuti azigwiritsidwa ntchito pakamwa.
Ntchito:
Acetaminophen amagwiritsidwa ntchito kwambiri kuchepetsa ululu komanso kuchepetsa kutentha thupi. Amadziwika kuti amathandiza kuthetsa ululu wochepa mpaka pang'ono, monga kupweteka kwa mutu, kupweteka kwa minofu, ndi mano. Mosiyana ndi mankhwala oletsa kutupa (nonsteroidal anti-inflammatory drugs) (NSAIDs), acetaminophen ilibe katundu wotsutsa-kutupa.
Njira yeniyeni yogwiritsira ntchito acetaminophen sikumveka bwino, koma imakhulupirira kuti imaphatikizapo kuletsa kwa enzyme yotchedwa cyclooxygenase (COX) m'kati mwa dongosolo la mitsempha. Enzyme imeneyi imakhudzidwa ndi kupanga ma prostaglandins, omwe amathandizira kuzindikira zowawa ndikuwongolera kutentha kwa thupi.
Acetaminophen imatengedwa ngati njira yotetezeka yochepetsera ululu mwa anthu omwe sangathe kulekerera NSAID chifukwa cha zinthu monga zilonda zam'mimba kapena matenda a magazi.
Kafukufuku wofananira:
Maphunziro a in vitro In vitro, acetaminophen inachititsa kusankha kwa 4.4-fold kwa COX-2 inhibition (IC50 ya COX-1, 113.7 μM; IC50 ya COX-2, 25.8 μM). Pambuyo pakamwa, kuletsa kwa ex vivo kwakukulu kunali 56% (COX-1) ndi 83% (COX-2). Kuchuluka kwa acetaminophen mu plasma kunakhalabe pamwamba pa in vitro IC50 ya COX-2 kwa maola osachepera asanu mutatha kumwa. Miyezo ya ex vivo IC50 ya acetaminophen (COX-1: 105.2 μM; COX-2: 26.3 μM) imafananiza bwino ndi mu vitro IC50. Mosiyana ndi malingaliro akale, acetaminophen imalepheretsa COX-2 ndi oposa 80%, digiri yofanana ndi mankhwala osagwiritsidwa ntchito poletsa kutupa (NSAIDs) ndi COX-2 inhibitors. Komabe, palibe> 95% COX-1 blockade yakhala ikugwirizana ndi kuletsa ntchito ya mapulateleti [1]. Kuyeza kwa MTT kunawonetsa kuti acetaminophen (APAP) pa mlingo wa 50mM kwambiri (p
Maphunziro a mu vivo: Kulamulira kwa acetaminophen (250 mg/kg, pakamwa) kwa mbewa kunachititsa kuti chiwindi chiwonongeke kwambiri (p