Kugulitsa kotentha CAS 52232-67-4 Teriparatide acetate mtengo wabwino wotetezeka kubweretsa kwamtundu wapamwamba kwambiri wogulitsa wotentha komanso kukhutira kwamakasitomala

Dzina Lodziwika:Teriparatide acetate

Nambala ya CAS: 52232-67-4

Kulemera kwa Maselo: 4177.77000

Maselo amtundu:C181H291N55O51S2

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Dzina Lonse	Teriparatide acetate
Nambala ya CAS	52232-67-4
Kulemera kwa Maselo	4177.77000
Molecular Formula	Mtengo wa C181H291N55O51S2
Malingaliro a kampani EINECS	640-978-1
Kukhazikika	Hygroscopic
Maonekedwe	ufa
Mkhalidwe wosungira	-20 ° C

Kanema wa Zamalonda

Kugwiritsa Ntchito Mankhwala

Teriparatide ndi agonist wa PHT, ndipo mtengo wake wa IC50 m'maselo a HEK293 ndi 2 nM.Teripartite ikhoza kugwirizanitsa mafupa a metabolism mwa kuletsa osteoblast apoptosis, kuyambitsa maselo a mafupa ndi kupititsa patsogolo kusiyana kwa osteoblast. Poyang'anira njira ya adenylate cyclase-cyclic adenosine monophosphate-protein kinase A, PHT-ⅰ zolandilira pamwamba pa osteoblasts, maselo ozungulira mafupa ndi ma cell a m'mafupa amatsitsimutsidwa pang'onopang'ono kulimbikitsa kusiyanitsa kwa osteoblasts ndikutalikitsa moyo wawo. Limbikitsani kuchulukira kwa ma cell a osteoblast kudzera pa phosphate C- cytoplasmic calcium ion-protein kinase Chemibook C njira yopatsira chizindikiro; Poletsa ntchito ya trans-activation ya PPARγ, kusiyanitsa kwa maselo a stromal kukhala mizere ya adipocyte kumachepetsedwa ndipo chiwerengero cha osteoblasts chikuwonjezeka. Kuwongolera kosalunjika kwa kukula kwa mafupa mwa kuyang'anira ma cytokines, mwachitsanzo, kungapangitse iGF-1 kuti igwirizane ndi osteoblasts, motero kulimbikitsa mapangidwe a mafupa; Wnt signing pathway imayang'anira njira yopangira mafupa, motero imakulitsa mapangidwe a mafupa.

Zambiri Zamakampani

Demei Pharmaceutical Technology Co., Ltd.ndi bizinesi yamphamvu komanso yotsogola yomwe imagwira ntchito pa kafukufuku, kupanga, ndi kugawa kwamankhwala apamwamba kwambiri komanso ma organic compounds. Ndi kudzipereka kolimba kupititsa patsogolo makampani opanga mankhwala padziko lonse lapansi, timadzipereka kuti tithandizire kutumiza kunja kwa mankhwala aku China padziko lonse lapansi. Zogulitsa zathu zambiri zadziwika bwino m'misika yayikulu, kuphatikiza UK, Germany, Australia, Netherlands, Poland, Russia, Kazakhstan, Philippines, Malaysia, Singapore, ndi madera ena ambiri. Povomereza mfundo za kukhulupirika ndi kuwonekera, timayika patsogolo kumanga maubwenzi odalirika ndi makasitomala athu, kuonetsetsa kuti zonse zikuyenda bwino komanso mgwirizano wautali.