Kugulitsa kotentha kwafakitale CAS 218949-48-5 Tesamorelin yokhala ndi mtengo wamtengo wapatali wogulitsidwa wotentha kwambiri komanso kutumiza khomo ndi khomo

Timorelin imapangidwa ndi 44 amino acid sequences of human growth hormone releasing factor (GRF), yokhala ndi 3-hexenyl yophatikizidwa ndi tyrosine N-terminal residue. Ndi buku la kukula kwa timadzi timene timatulutsa analogi, lomwe silingangobwezeretsa katulutsidwe kabwino ka kukula kwa timadzi mu vivo, komanso kuchepetsa kuchuluka kwa minofu ya visceral adipose (VAT), kupititsa patsogolo dyslipidemia ndi moyo wabwino, komanso kukhalabe ndi moyo wabwino. glucose mu vivo. Timorelin ndi analogue yopangidwa ndi kukula kwa hormone releasing factor (GRF). Mofanana ndi endogenous GRF, imagwira ntchito mu vitro pomanga ndi kuyambitsa GRF zolandilira. GRF ndi hypothalamic regulatory polypeptide, yomwe imatha kulimbikitsa ma cell a pituitary kukula kuti apange ndikutulutsa timadzi tating'onoting'ono ta kukula (GH). GH imagwira ntchito ya pharmacological poyanjana ndi zolandilira zenizeni za maselo omwe akutsata, kuphatikizapo chondrocytes, osteoblasts, cardiomyocytes, hepatocytes ndi adipocytes. Ndiwoyenera kuchiza matenda am'mimba mwa odwala omwe ali ndi kachilombo ka HIV omwe ali ndi lipodystrophy.