CAS 69440-99-9 Thymalfasin yokhala ndi kugulitsa kotentha kwambiri padziko lonse lapansi kukhutitsidwa kwamakasitomala komanso kutumiza mwachangu

Thymalfasin ndi mtundu wa mapuloteni ndi mahomoni a polypeptide omwe ali ndi mphamvu zowonjezera chitetezo cha mthupi, zomwe zimapangidwa ndi maselo a epithelial mu cortex yapamwamba ndi medulla ya thymus. Ndi acidic polypeptide yopangidwa ndi 28 amino acid. Ndiloyang'anira mayankhidwe achilengedwe okhala ndi zochitika zambiri zamoyo. Amagwiritsidwa ntchito kwambiri pochiza immunodeficiency, tizilombo toyambitsa matenda ndi zotupa kuchipatala. Ndi mankhwala oyamba ochizira matenda a chiwindi a B, ndipo angagwiritsidwenso ntchito ngati mankhwala adjuvant pa katemera. The achire zotsatira zake ndi zodabwitsa. Lili ndi ubwino wa ntchito zambiri, zochepa poizoni ndi zotsatira zake ndi zisonyezo lonse. Thymalfasin imatha kukulitsa ntchito ya maselo a P, kulimbikitsa kupanga ma lymphocyte, kuwongolera kuchuluka kwa magawo a P cell, kusiyanitsa kwa ma cell a U ndi kupanga ma antibody, kulimbikitsa kupanga ma antiviral lymphatic factor ndi macrophages, kupititsa patsogolo phagocytosis, ndikuwongolera chitetezo cham'thupi. odwala chotupa. Imathanso kuchotsa mabakiteriya, mafangasi ndi ma virus m'thupi. Njira yatsopano ya thymic imagwiritsidwa ntchito ku dongosolo la mitsempha ndi kuzungulira endothelium, yomwe imagwira ntchito yoyendetsa kayendedwe ka synaptic ya hippocampal neurons. Thymalfasin imakhudza kufalikira kwa ma synapses osangalatsa komanso dongosolo lamanjenje, ndipo itha kugwiritsidwa ntchito kupewa neurotoxicity yomwe imayambitsidwa ndi chemotherapy ndi mankhwala ena oletsa khansa kwa odwala khansa. Thymalfasin ili ndi ntchito yowongolera ma jini, omwe amatha kupangitsa majini a kinase cascade, kuwongolera majini a cytokine komanso majini owongolera chitetezo chamthupi. Mphamvu yowonjezereka ya thymalfasin pa jini ya Toil-like receptor ikuwonetsa kuti thymalfasin imatha kulimbikitsa ma cell owonetsa ma antigen. Udindo wa thymidine pakukula kwa ma cell a chitetezo chamthupi ukuwonekera pakuwongolera kwa stem cell growth factor ndi hematopoietic protein gene expression.