Site na mmepe na-aga n'ihu na ntozu nke ụlọ ọrụ kemịkalụ, ụlọ ọrụ anyị na-enwekwu ahụmahụ na ogologo ụzọ nke ilekwasị anya na akụrụngwa ọgwụ, ọ bụghị naanị na njikwa nke ngwaahịa ngwaahịa, kamakwa na nlekọta nke ndị ọrụ tupu na mgbe ire ere. , na iwebata akụrụngwa ngwaahịa. Iwu siri ike nke nkwalite na nkwalite emeela ka ụlọ ọrụ anyị na-aga n'ihu na-aga n'ihu, akụkụ nke mpaghara ndị ahịa na-abawanye ụba, na azụmahịa azụmahịa na-agbasawanye kwa afọ, gụnyere mmepe na nyocha nke ihe ịchọ mma. Na mgbakwunye, ụlọ ọrụ anyị nwere ugbu a ọrụ ọhụrụ na-aga n'ihu n'ihe gbasara akụrụngwa ọgwụ. Ugbu a, anyị na-ewu ebe mmepụta ihe karịrị mita 7,000 ka ọ bụrụ ọkachamara na mmepụta nke resveratrol, na-agbalịsi ike ịghọ onye na-emepụta ihe na-emepụta resveratrol. soplaya.
Yabụ kedu ihe bụ resveratrol? Ka m nye gị okwu mmalite dị nkenke.
Resveratrol (3-4'-5-trihydroxystilbene) bụ ihe na-abụghị flavonoid polyphenol compound nke aha kemịkal bụ 3,4',5-trihydroxy-1,2-diphenylethylene (3,4',5-Stilbenetriol), usoro ihe omimi. bụ C14H12O3, na molekụla arọ bụ 228.25. Ọdịdị nke resveratrol dị ọcha na-acha ọcha na ntụ ntụ edo edo, enweghị isi, siri ike igbari na mmiri, na-adị mfe soluble na organic solvents dị ka ether, chloroform, methanol, ethanol, acetone, ethyl acetate, wdg, na agbaze nke 253 ~ 255°C. Sublimation okpomọkụ bụ 261 ℃. Ọ nwere ike ịpụta ọbara ọbara na ngwọta alkaline dị ka mmiri amonia, ma nwee ike imeghachi omume na ferric chloride-potassium ferricyanide iji mepụta agba. Enwere ike iji ihe onwunwe a chọpụta resveratrol.
Natural resveratrol nwere ihe owuwu abụọ, cis na trans. Ọ kachasị dị na trans conformation na ọdịdị. Enwere ike ijikọ ụlọ abụọ ahụ na glucose n'otu n'otu iji mepụta cis na trans resveratrol glycosides. Cis- na trans-resveratrol glycosides nwere ike ịhapụ resveratrol n'okpuru ọrụ glycosidases na eriri afọ. N'okpuru irradiation ọkụ UV, trans-resveratrol nwere ike ịtụgharị n'ime cis-isomer.
Resveratrol na-emepụta fluorescence n'okpuru 366nm ultraviolet ìhè. Jeandet et al. kpebisiri ike na njirimara UV spectral resveratrol na infrared absorption kacha elu na 2800 ~ 3500cm (OH bond) na 965cm (trans form of two bond). Nnwale egosiwo na trans-resveratrol kwụsiri ike ọbụlagodi na ọ hapụrụ ya ruo ọtụtụ ọnwa, ma e wezụga na pH buffers dị elu, ọ bụrụhaala na ọ dịpụrụ adịpụ na ìhè.
Resveratrol nwere obere bioavailability n'ime ahụ, na ọmụmụ na-egosi na bioavailability nke resveratrol metabolites na obere eriri afọ na imeju bụ ihe dịka 1%. Resveratrol na-eme ngwa ngwa metabolized na anụmanụ ma rute ọnụ ahịa kacha elu na plasma n'ime nkeji ise. Ọmụmụ metabolism na anụmanụ achọpụtala na resveratrol na-abụkarị metabolized na anụ mammals dị ka oke, ezì, nkịta, wdg n'ụdị resveratrol sulfate esterification na ngwaahịa glucuronidation. Nnyocha e mere egosiwo na a na-ekesa resveratrol n'ụdị agbụ n'ime anụ ahụ dị iche iche nke anụ mammals, na resveratrol na-etinyekwu obi ma na-ekesa n'ime akụkụ ahụ ndị nwere ọbara ọgbụgba bara ụba, dị ka imeju, akụrụ, obi na ụbụrụ. Site na nyocha banyere metabolism nke resveratrol n'ime ahụ mmadụ, a chọpụtara na ntinye nke resveratrol na plasma nke mmadụ nkịtị gosipụtara "ihe dị elu okpukpu abụọ" mgbe nchịkwa ọnụ gasịrị, mana ọ nweghị ihe dị otú ahụ mgbe nchịkwa iv gasịrị (ịgba ọgwụ intravenous) ; ntinye nke resveratrol na plasma mgbe nchịkwa ọnụ gasịrị Isi ngwaahịa nke metabolism mmanya bụ glucuronidation na sulfate esterification. Mgbe ndị ọrịa nwere ọrịa cancer colorectal were ọnụ resveratrol, eriri aka ekpe na-amịkọrọ ihe na-erughị akụkụ aka nri, a na-enwetakwa metabolites isii, resveratrol-3-O-glucuronide na resveratrol-4′-O-glucuronide. Resveratrol sulfate na glucuronide ogige dị ka glucuronide, resveratrol-3-O-sulfate, na resveratrol-4′-O-sulfate.
