Ihe gbasara CAS 103-90-2 acetaminophen

Nkọwa:

Acetaminophen, nke a makwaara dị ka paracetamol, bụ ngwakọta kemịkalụ nwere usoro molekụla C8H9NO2. Ọ bụ ọgwụ na-adaba n'okpuru klas nke analgesics (ndị na-enye mgbu) na antipyretics (ndị na-ebelata ahụ ọkụ). N'usoro, acetaminophen bụ ihe nrụpụta para-aminophenol. N'ihe gbasara akụrụngwa anụ ahụ, acetaminophen bụ ntụ ntụ kristal na-acha ọcha nke na-agbaze na mmiri. A na-enweta ya n'ụdị dị iche iche, gụnyere mbadamba, capsules, na nkwusioru mmiri mmiri, maka nchịkwa ọnụ.

eji:

A na-eji acetaminophen eme ihe n'ọtụtụ ebe iji belata mgbu ma belata ahụ ọkụ. A maara ya maka ịdị irè ya n'ibelata mgbu dị nro na nke na-adịghị ala ala, dị ka isi ọwụwa, ahụ mgbu na eze mgbu. N'adịghị ka ọgwụ mgbochi mkpali na-adịghị steroidal (NSAIDs), acetaminophen enweghị nnukwu ihe mgbochi mkpali.

Aghọtachaghị usoro nke acetaminophen n'ụzọ zuru oke, mana ekwenyere na ọ gụnyere mgbochi nke enzyme a na-akpọ cyclooxygenase (COX) na sistemu ụjọ nke etiti. Enzyme a na-etinye aka na mmepụta nke prostaglandins, nke na-ekere òkè na nghọta mgbu na nhazi nke okpomọkụ ahụ.

A na-ewere acetaminophen dị ka nhọrọ dị nchebe maka enyemaka mgbu na ndị na-enweghị ike ịnagide NSAID n'ihi ihe ndị dị ka ọnya afọ ma ọ bụ ọrịa ọgbụgba ọbara.

Nchọpụta emetụtara

In vitro ọmụmụ In vitro, acetaminophen mere ka 4.4-fold selectivity maka COX-2 mgbochi (IC50 maka COX-1, 113.7 μM; IC50 maka COX-2, 25.8 μM). Mgbe nchịkwa ọnụ gasịrị, mgbochi ex vivo kacha bụ 56% (COX-1) na 83% (COX-2). Ntụle plasma acetaminophen dị n'elu in vitro IC50 nke COX-2 opekata mpe awa 5 ka emechara ya. Ụkpụrụ ex vivo IC50 nke acetaminophen (COX-1: 105.2 μM; COX-2: 26.3 μM) tụnyere nke ọma na ụkpụrụ in vitro IC50. N'adịghị ka echiche ndị gara aga, acetaminophen na-egbochi COX-2 site na ihe karịrị 80%, ogo nke yiri ọgwụ mgbochi mkpali na-adịghị steroidal (NSAIDs) na nhọrọ COX-2 inhibitors. Agbanyeghị, ọ nweghị> 95% COX-1 mgbochi ejirila na mgbochi nke ọrụ platelet [1]. MTT nyocha gosiri na acetaminophen (APAP) na dose nke 50mM budata (p