Cov tshuaj tshiab rau kev mob kev nkeeg

Thaum Lub Tsib Hlis 15, Vanda Pharmaceuticals, lub tuam txhab biopharmaceutical hauv Teb Chaws Asmeskas, tshaj tawm tias qhov thib ob txoj kev tshawb fawb III ntawm nws cov tshuaj tshiab Tradipitant (tradipitant) rau kev kho mob ntawm kev mob kev nkeeg (tshwj xeeb yog kev mob nkeeg) tau ua tiav cov txiaj ntsig zoo.
Tradipitant yog neurokinin-1 (NK1) receptor antagonist tsim los ntawm Eli Lilly. Vanda tau txais txoj cai kev loj hlob thoob ntiaj teb ntawm Tradipitant los ntawm kev tso cai thaum lub Plaub Hlis 2012.
Tam sim no, Vanda tau tsim Tradipitant rau cov cim qhia xws li atopic dermatitis pruritus, gastroparesis, kab mob coronavirus tshiab, kev mob kev nkeeg, kev quav dej caw, kev phobia, thiab kev zom zaub mov.
Qhov kev tshawb fawb Theem 3 no suav nrog 316 cov neeg mob uas muaj kev mob nkeeg uas muaj keeb kwm ntawm kev mob ntshav qab zib, uas tau kho nrog 170 mg Tradipitant, 85 mg Tradipitant, lossis placebo thaum caij nkoj.
Txhua tus neeg koom nrog kev kawm tau muaj keeb kwm ntawm kev mob seasickness. Thawj qhov kawg ntawm txoj kev tshawb no yog cov nyhuv ntawm tradipitant (170 mg) rau ntuav. Cov ntsiab lus tseem ceeb thib ob yog: (1) cov nyhuv ntawm tradipitant (85 mg) rau ntuav; (2) cov nyhuv ntawm tradipitant hauv kev tiv thaiv mob xeev siab thiab ntuav.
Nws tau tshaj tawm tias kev mob hnyav tseem yog qhov kev xav tau kev kho mob tsis tau. Lub US Food and Drug Administration (FDA) tsis tau pom zoo rau cov tshuaj tshiab rau kev kho mob ntawm kev mob kev nkeeg rau ntau tshaj 40 xyoo txij li thaum nws pom zoo scopolamine (ib tug transdermal thaj tso rau hauv qab pob ntseg) nyob rau hauv 1979.

Raws li cov ntaub ntawv los ntawm ob qhov kev tshawb fawb Phase III, Vanda yuav xa daim ntawv thov kev lag luam rau cov neeg lag luam mus rau FDA rau kev kho mob ntawm cov kab mob hauv lub quarter thib plaub ntawm 2024.