Hot Tags: CAS 16941-32-5 Glucagon nrog purity siab zoo zoo tus nqi kub muag khoom lub qhov rooj rau qhov rooj xa thiab siab cov neeg siv khoom txaus siab.

Lub luag haujlwm tseem ceeb ntawm glucagon yog txhawb nqa glycogen decomposition thiab tsim cov piam thaj kom nce ntshav qab zib; Qhov thib ob, theem ntawm cyclic adenosine monophosphate (cAMP) tuaj yeem nce los ntawm adenylate cyclase, yog li ua kom cov protein kinase, ua kom lipase hauv cov ntaub so ntswg adipose thiab txhawb lipolysis. Ua kom cov kab mob myocardial adenylate cyclase, txhawb kev ua haujlwm ntawm myocardial phosphorylase, ua kom cov calcium ntau ntxiv hauv myocardium, yog li txhim kho myocardial contractility, ua rau lub plawv dhia thiab nce ntshav siab; Nws tseem tuaj yeem txhawb nqa kev zais ntawm islet Chemicalbook, somatostatin, thyroxine thiab calcitonin; Txhawb kev tso tawm catecholamine los ntawm sympathetic paj hlwb thiab chromaffin hlwb. Glucagon, insulin thiab somatostatin tswj ib leeg kom cov ntshav qab zib nyob hauv qhov qub. Kev tso tawm ntawm glucagon yog inversely proportional rau cov ntshav qabzib concentration, thiab tib lub sijhawm, kev tso tawm ntawm glucagon tseem cuam tshuam los ntawm cov amino acids, plasma dawb fatty acid cov ntsiab lus, α -adrenergic receptor stimulator (norepinephrine), auxin tso tawm inhibitory hormone thiab yog li ntawd.

Glucagon yog ib leeg-chain polypeptide hormone synthesized thiab secreted los ntawm islet α2 hlwb. Nws yog ib qho physiological antagonist ntawm insulin. Cov nyhuv ntawm cov metabolism zoo ib yam li adrenaline, thiab nws muaj cov haujlwm hauv qab no: 1. Kev ua haujlwm ntawm kev nce ntshav qab zib: nws tuaj yeem qhib cov phosphorylase hauv daim siab, txhawb lub decomposition ntawm daim siab glycogen thiab heterogenesis ntawm glycogen, thiab nce. ntshav qab zib. 2. Cov txiaj ntsig zoo inotropic: nws tuaj yeem ua rau cov ntsiab lus ntawm intracellular cAMP, txhim khu myocardial contractility, ua rau kom lub plawv tso zis thiab mob stroke. Nws cov txiaj ntsig zoo inotropic tseem tuaj yeem siv tau tom qab siv lub plawv glycoside txaus, thiab nws tsis thaiv los ntawm propranolol. Txawm hais tias nws tuaj yeem ua rau lub plawv dhia thiab kub siab, nws yuav tsis ua rau arrhythmia. Cov txheej txheem yog raws li hauv qab no: ① Ua kom cov adenylate cyclase ua rau adenosine triphosphate hloov mus rau hauv cyclic adenosine monophosphate, uas txhim kho cov myocardial contractility ntawm Chemicalbook; ② Txhawb kev decomposition ntawm daim siab glycogen thiab nce qib ntshav qab zib; ③ Txhawb nqa insulin tso tawm, txhim kho kev siv cov piam thaj los ntawm myocardium, thiab txhawb nqa anaerobic glycolysis ntawm myocardium, yog li txhim kho lub zog metabolism ntawm myocardium. Ua ke nrog digitalis cardiac glycosides, nws tuaj yeem ua kom cov nyhuv curative. 3. Cov nyhuv ntawm lub raum: dilate lub raum cov hlab ntsha, txhim kho lub raum cov ntshav khiav thiab txhawb kev tso tawm ntawm sodium, potassium thiab calcium. 4. Cov nyhuv ntawm lub plab zom mov: Nws tuaj yeem ua rau cov leeg du ntawm lub plab thiab duodenum, cov hnyuv me thiab cov hnyuv, inhibit peristalsis ntawm lub plab, cov hnyuv me thiab cov hnyuv, thiab ua rau kom cov kua tsib thiab cov kua tsib. 5. Kev cuam tshuam ntawm cov kab mob zais zis: Ua rau adrenal medulla thiab txhawb kev tso tawm catecholamines. Nws tseem tuaj yeem txhawb kev tso tawm ntawm insulin, thyroid hormone, calcitonin thiab kev loj hlob hormone.