E pili ana i CAS 103-90-2 Acetaminophen

wehewehe:

ʻO ka Acetaminophen, ka mea i kapa ʻia ʻo paracetamol, he mea hoʻohui kemika me ke ʻano molekala C8H9NO2. He lāʻau lapaʻau ia e hāʻule ana ma lalo o ka papa o nā analgesics (nā mea hoʻomaha ʻeha) a me nā antipyretics (mea hoʻemi i ke kuni). Ma ke ʻano, ʻo ka acetaminophen kahi derivative para-aminophenol. Ma ke ʻano o nā waiwai kino, ʻo ka acetaminophen he pauka keʻokeʻo keʻokeʻo i hiki ke hoʻoheheʻe ʻia i ka wai. Loaʻa maʻamau i loko o nā ʻano hana like ʻole, me nā papa, nā capsules, a me nā hoʻokuʻu wai, no ka hoʻoponopono waha.

Hoʻohana:

Hoʻohana nui ʻia ka Acetaminophen e hoʻēmi i ka ʻeha a hoʻemi i ke kuni. Ua ʻike ʻia no ka maikaʻi o ka hoʻomaha ʻana i ka ʻeha maʻalahi, e like me ke poʻo, nā ʻiʻo, a me nā ʻeha niho. ʻAʻole like me nā lāʻau anti-inflammatory nonsteroidal (NSAIDs), ʻaʻohe waiwai anti-inflammatory koʻikoʻi ka acetaminophen.

ʻAʻole maopopo loa ke ʻano o ka hana o ka acetaminophen, akā manaʻo ʻia ʻo ia ke komo ʻana i ka inhibition o kahi enzyme i kapa ʻia ʻo cyclooxygenase (COX) i loko o ka ʻōnaehana nerve waena. Hoʻokomo ʻia kēia enzyme i ka hana ʻana o nā prostaglandins, kahi mea e hana ai i ka ʻike ʻeha a me ka hoʻoponopono ʻana i ka mahana o ke kino.

Manaʻo ʻia ʻo Acetaminophen he koho palekana no ka hoʻomaha ʻana i ka ʻeha i nā poʻe ʻaʻole hiki ke ʻae i nā NSAID ma muli o nā kumu e like me ka maʻi ʻeha a me nā maʻi koko.

Ka noiʻi pili:

Nā haʻawina in vitro In vitro, acetaminophen i hana i ka 4.4-fold selectivity no ka COX-2 inhibition (IC50 no COX-1, 113.7 μM; IC50 no COX-2, 25.8 μM). Ma hope o ka hoʻoponopono waha, ʻo ka nui o ka ex vivo inhibition he 56% (COX-1) a me 83% (COX-2). Noho ʻia ka nui o ka plasma acetaminophen ma luna o ka in vitro IC50 o COX-2 no ka liʻiliʻi o 5 mau hola ma hope o ka lawe ʻana. Hoʻohālikelike ʻia nā waiwai ex vivo IC50 o ka acetaminophen (COX-1: 105.2 μM; COX-2: 26.3 μM) me kāna mau waiwai in vitro IC50. Kū'ē i nā manaʻo mua, hoʻokaʻawale ka acetaminophen i ka COX-2 ma mua o 80%, kahi degere e like me nā lāʻau anti-inflammatory nonsteroidal (NSAIDs) a me nā mea koho COX-2 inhibitors. Eia nō naʻe, ʻaʻole i pili i ka 95% COX-1 blockade me ka pale ʻana i ka hana platelet [1]. Ua hōʻike ʻo MTT assay i ka acetaminophen (APAP) ma kahi maʻa o 50mM nui (p