0102030405
Kūʻai wela CAS 597562-32-8 LL-37 amide trifluoroacetate paʻakai Mea hana hoʻolako i nā mea waiwai maikaʻi loa ke kumu kūʻai maikaʻi loa.
Hoʻohana huahana
ʻO LL-37 kahi peptide antimicrobial kanaka o ka ʻohana cathelicidin a pili i ka māhele 134-170 o ke kanaka cationic antimicrobial protein 18 (hCAP18). He kuleana koʻikoʻi ia i ka laina mua o ka pale ʻana i ka maʻi kūloko a me ka hoʻouka ʻana o nā pathogens ma nā wahi o ka mumū a me nā ʻeha. ʻO Cytotoxic i nā pūnaewele eukaryotic bacterial a maʻamau, ʻo LL-37 ke kūpaʻa nui i ka proteolytic degradation i ka hopena.
kikoʻī huahana
| CAS No. | 597562-32-8 |
| Kumukumu | C205H341N61O52 |
| Kaumaha Molecular | 4492.358 |
| Waihona | nā kūlana -20 ° C, pale ʻia mai ka mālamalama |
wehewehe huahana
ʻO LL-37, i kapa ʻia ʻo hCAP18, no ka ʻohana cathelicidins o nā peptides antimicrobial nona ka hana antimicrobial ikaika ma waena o nā ʻano he nui. I loko o ke kanaka, ʻo kēia wale nō ka cathelicidin i loaʻa, a ua hana ʻia ia i loko o nā cell epithelial ma o ka proteolytic cleavage o ka protein hCAP-18. Ma kahi o kāna mau waiwai antimicrobial, LL-37 kekahi hana koʻikoʻi i ka hoʻoponopono ʻana i ka ʻōnaehana pale. Hiki iā ia ke pale i nā pane ʻeha ma ke kāohi ʻana i ka hoʻāla ʻana o TLR2 a me TLR4, ka mea e ʻike i nā ʻāpana like ʻole o nā paia cell bacteria.
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