Tare da ci gaba da ci gaba da balaga da masana'antar sinadarai, kamfaninmu ya zama mafi ƙwarewa a cikin dogon hanya na mayar da hankali kan albarkatun magunguna, ba kawai a cikin kula da ingancin samfurin ba, har ma a cikin kulawar ma'aikata kafin da bayan tallace-tallace. , da kuma gabatar da kayan aikin samfur. Abubuwan da ake buƙata na haɓakawa da haɓakawa sun sa kamfaninmu ya ci gaba da ci gaba, yawan yankunan abokan ciniki yana karuwa da yawa, kuma kasuwancin kasuwancin yana fadada kowace shekara, ciki har da ci gaba da bincike na kayan aikin kwaskwarima. Bugu da kari, kamfaninmu a halin yanzu yana da sabbin ayyuka na ci gaba dangane da albarkatun magunguna. Yanzu muna gina wani yanki na samar da fiye da murabba'in murabba'in 7,000 don ƙware a cikin samar da resveratrol, ƙoƙarin zama babban mai samar da resveratrol. mai bayarwa.
To, menene ainihin resveratrol? Bari in baku takaitaccen bayani.
Resveratrol (3-4'-5-trihydroxystilbene) wani fili ne maras flavonoid polyphenol wanda sunansa sunansa shine 3,4',5-trihydroxy-1,2-diphenylethylene (3,4',5-Stilbenetriol), tsarin kwayoyin halitta. shine C14H12O3, kuma nauyin kwayoyin shine 228.25. Bayyanar resveratrol mai tsabta shine fari zuwa launin rawaya mai haske, maras wari, mai wuyar narkewa a cikin ruwa, sauƙi mai narkewa a cikin kwayoyin halitta kamar ether, chloroform, methanol, ethanol, acetone, ethyl acetate, da dai sauransu, tare da ma'anar narkewa na 253 ~ 255°C. Sublimation zafin jiki ne 261 ℃. Yana iya bayyana ja tare da maganin alkaline kamar ruwan ammonia, kuma yana iya amsawa tare da ferric chloride-potassium ferricyanide don haɓaka launi. Ana iya amfani da wannan kadarar don gano resveratrol.
Resveratrol na halitta yana da tsari guda biyu, cis da trans. Ya fi wanzuwa a cikin yanayin canzawa cikin yanayi. Za a iya haɗa tsarin biyu tare da glucose bi da bi don samar da cis da trans resveratrol glycosides. Cis- da trans-resveratrol glycosides na iya sakin resveratrol a ƙarƙashin aikin glycosidases a cikin hanji. A ƙarƙashin hasken UV, ana iya canza trans-resveratrol zuwa cis-isomer.
Resveratrol yana samar da haske a ƙarƙashin hasken ultraviolet na 366nm. Jeandet et al. Ƙaddamar da halaye na UV na resveratrol da kololuwar infrared ɗin sa a 2800 ~ 3500cm (OH bond) da 965cm (nau'in nau'in haɗin kai biyu). Gwaje-gwaje sun nuna cewa trans-resveratrol yana da ƙarfi ko da an bar shi tsawon watanni da yawa, sai dai a cikin manyan pH buffers, muddin ya keɓe gaba ɗaya daga haske.
Resveratrol yana da ƙarancin bioavailability a cikin jiki, tare da binciken da ke nuna cewa bioavailability na resveratrol metabolites a cikin ƙananan hanji da hanta kusan 1%. Resveratrol yana da sauri metabolized a cikin dabbobi kuma ya kai kololuwar darajarsa a cikin jini cikin mintuna 5. Nazarin Metabolism a cikin dabbobi sun gano cewa resveratrol yana haɓakawa a cikin dabbobi masu shayarwa kamar berayen, alade, karnuka, da dai sauransu a cikin nau'in resveratrol sulfate esterification da samfuran glucuronidation. Nazarin ya tabbatar da cewa resveratrol yana rarraba a cikin nau'i na nau'i na nau'i daban-daban na dabbobi masu shayarwa, kuma resveratrol ya fi sha kuma yana rarrabawa a cikin gabobin da ke da tarin jini, kamar hanta, kodan, zuciya da kwakwalwa. Ta hanyar bincike kan metabolism na resveratrol a cikin jikin mutum, an gano cewa maida hankali kan resveratrol a cikin plasma na mutane na yau da kullun ya nuna "al'amari biyu kololuwa" bayan gudanar da baki, amma babu irin wannan lamarin bayan gudanar da iv (alurar rigakafi) ; Matsakaicin resveratrol a cikin plasma bayan gudanar da baki Babban samfuran metabolism na barasa shine glucuronidation da sulfate esterification. Bayan marasa lafiya da ke fama da cutar kansar launi suna shan resveratrol da baki, hanjin hagu yana sha ƙasa da gefen dama, kuma ana samun metabolites shida, resveratrol-3-O-glucuronide da resveratrol-4′-O-glucuronide. Resveratrol sulfate da glucuronide mahadi irin su glucuronide, resveratrol-3-O-sulfate, da resveratrol-4′-O-sulfate.
