Game da CAS 103-90-2 Acetaminophen
2024-05-10 09:37:28
| Wurin narkewa | 168-172 ° C (lit.) |
| Wurin tafasa | 273.17°C |
| yawa | 1,293 g/cm3 |
| tururi matsa lamba | 0.008Pa a 25 ℃ |
| refractive index | 1.5810 |
| Fp | 11 °C |
| yanayin ajiya. | Yanayin rashin aiki, Zazzabin ɗaki |
| narkewa | ethanol: mai soluble0.5M, bayyananne, mara launi |
| pka | 9.86± 0.13 (An annabta) |
| tsari | Lu'ulu'u ko Crystalline foda |
| launi | Fari |
Bayani:
Acetaminophen, wanda kuma aka sani da paracetamol, wani sinadari ne mai hade da dabarar kwayoyin C8H9NO2. Magani ne da ke faɗuwa ƙarƙashin ajin analgesics (masu rage raɗaɗi) da antipyretics (masu rage zafin jiki). A tsari, acetaminophen shine asalin para-aminophenol. Dangane da kaddarorin jiki, acetaminophen wani farin lu'u-lu'u ne wanda ke narkewa cikin ruwa. Yawanci ana samunsa a cikin nau'ikan nau'ikan nau'ikan, gami da allunan, capsules, da dakatarwar ruwa, don gudanar da baki.
Amfani:
Ana amfani da acetaminophen sosai don rage zafi da rage zazzabi. An san shi don tasirinsa wajen kawar da ciwo mai laushi zuwa matsakaici, kamar ciwon kai, ciwon tsoka, da ciwon hakori. Sabanin magungunan da ba na steroidal anti-inflammatory ba (NSAIDs), acetaminophen ba shi da mahimmancin abubuwan hana kumburi.
Ba a fahimci ainihin tsarin aikin acetaminophen ba, amma an yi imanin ya haɗa da hana wani enzyme da ake kira cyclooxygenase (COX) a cikin tsarin kulawa na tsakiya. Wannan enzyme yana da hannu wajen samar da prostaglandins, wanda ke taka rawa wajen fahimtar jin zafi da kuma daidaita yanayin zafin jiki.
Ana ɗaukar Acetaminophen a matsayin mafi aminci zaɓi don jin zafi a cikin mutanen da ba za su iya jure wa NSAIDs ba saboda dalilai kamar ciwon ciki ko rashin zubar jini.
Bincike mai alaƙa:
Nazarin in vitro A cikin vitro, acetaminophen ya haifar da zaɓi na 4.4 don hana COX-2 (IC50 don COX-1, 113.7 μM; IC50 don COX-2, 25.8 μM). Bayan gudanar da baki, iyakar ex vivo hanawa shine 56% (COX-1) da 83% (COX-2). Matsalolin plasma acetaminophen ya kasance sama da na in vitro IC50 na COX-2 na aƙalla sa'o'i 5 bayan allura. The ex vivo IC50 dabi'u na acetaminophen (COX-1: 105.2 μM; COX-2: 26.3 μM) kwatanta da kyau tare da in vitro IC50 dabi'u. Sabanin ra'ayoyin da suka gabata, acetaminophen yana hana COX-2 da fiye da 80%, digiri mai kama da magungunan anti-inflammatory marasa steroidal (NSAIDs) da kuma masu hana COX-2 masu zaɓi. Koyaya, babu> 95% toshewar COX-1 da aka danganta da hana aikin platelet [1]. MTT assay ya nuna cewa acetaminophen (APAP) a kashi na 50mM mahimmanci (p
A cikin nazarin vivo: Gudanar da acetaminophen (250 mg / kg, baki) zuwa berayen sun haifar da mahimmanci (p